Assessment of the Impact of Gadolinium Injection on the Measurement of the QSM Signal

NCT ID: NCT04906941

Last Updated: 2026-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

73 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-21

Study Completion Date

2023-07-19

Brief Summary

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Patients meeting the inclusion and non-inclusion criteria will be offered to participate in the study. If they agree, they will perform an MRI without injection to obtain the QSM then perform the MRI with injection that was prescribed to them as part of the care, then they will perform a second time the MRI without injection to obtain the QSM. They will also answer a short questionnaire documenting their previous exposure to gadolinium.

Detailed Description

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Patients meeting the inclusion and non-inclusion criteria will be offered to participate in the study. If they agree, they will perform an MRI without injection to obtain the QSM then perform the MRI with injection that was prescribed to them as part of the care, then they will perform a second time the MRI without injection to obtain the QSM. They will also answer a short questionnaire documenting their previous exposure to gadolinium.

Conditions

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White Matter Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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MRI

SWI QSM 1.0iso 8 echos sequence performed before and after the injected MRI prescribed as part of the treatment.

\* Sense 2 \* 2: 9min33s

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* patients over 18 years old
* with an inflammatory CNS pathology
* to benefit as part of care from an MRI with injection of gadolinium
* consent to participate in the study
* beneficiary of a social protection scheme

Exclusion Criteria

* pregnant or breastfeeding woman
* patient benefiting from a legal protection measure
* Patient having performed more than 3 MRI exams with gadolinium injection during his life


* motion artifact not allowing image interpretation
* patient who has not completed one of the following sequences: T1 anatomical, FLAIR, or QSM pre-gadolinium injection.

Secondarily excluded patients will be replaced up to a maximum of 25 patients.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hhopital fondation adolphe de rothschild

Paris, Paris, France

Site Status

Countries

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France

Other Identifiers

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JSY_2021_14

Identifier Type: -

Identifier Source: org_study_id

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