Diffusion Magnetic Resonance Imaging (dMRI) in the Early Evaluation of Brain White Matter Diseases

NCT ID: NCT07108712

Last Updated: 2025-08-07

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-05-01
• Study Completion Date: 2025-12-01

Brief Summary

To assess the sensitivity and accuracy of diffusion magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI) metrics, in identifying early-stage changes in brain white matter related to various white matter diseases.

Detailed Description

Brain white matter diseases (WMDs) are a group of neurological conditions that involve changes to the brain's white matter, often leading to cognitive, motor, and sensory impairments.

Diffusion Magnetic Resonance Imaging (dMRI), has emerged as a powerful non-invasive imaging tool for evaluating microstructural changes in brain white matter. This protocol aims to investigate the role of dMRI in the early identification and characterization of brain white matter diseases, focusing on its potential for detecting abnormalities before the onset of overt clinical symptoms.

Diffusion-weighted imaging (DWI), one of the first advanced magnetic resonance imaging (MRI) techniques, has rapidly ascended on the basis of its applicability in strokes and some infectious diseases. Restricted diffusion is significant information in the context of vascular ischemia, helping to delimit the brain-damaged area

Conditions

Diffusion Magnetic Resonance Imaging; Brain White Matter Diseases

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Study group

Patients diagnosed with suspected early-stage white matter disease (e.g., multiple sclerosis, small vessel disease, Alzheimer's disease, frontotemporal dementia, leukoaraiosis) will be enrolled.

Magnetic Resonance Imaging (MRI)

Intervention Type: OTHER

Magnetic Resonance Imaging (MRI) Scanner: All imaging will be performed using a 1.5 tesla MRI scanner to ensure high resolution and signal-to-noise ratio.

Interventions

Magnetic Resonance Imaging (MRI)

Magnetic Resonance Imaging (MRI) Scanner: All imaging will be performed using a 1.5 tesla MRI scanner to ensure high resolution and signal-to-noise ratio.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Adults aged 18-80 years.
• Clinical suspicion of early-stage white matter disease.
• No prior diagnosis of significant neurological disorders (e.g., stroke, brain tumors).
• Ability to provide informed consent.

Exclusion Criteria

• Pregnancy or breastfeeding.
• Contraindications for magnetic resonance imaging (MRI) (e.g., metal implants, pacemakers).
• Severe psychiatric or cognitive impairment that prevents participation.
• Control Group: Healthy individuals without any clinical history of neurological diseases, matched by age and sex to the patient cohort.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The General Authority for Teaching Hospitals and Institutes

NETWORK

Sponsor Role: lead

Responsible Party

Hekmat Samir Baumey

Lecturer of Diagnostic Radiology, Damnhour National Medical Institute

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

General Authority for Teaching Hospitals and Institutes

Cairo, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Hekmat S Baumey, MD

Role: CONTACT

hekmattsamir@gmail.com

00201555433546

Facility Contacts

Hekmat S Baumey, MD

Role: primary

hekmattsamir@gmail.com

00201555433546

Other Identifiers

HD000235

Identifier Type: -

Identifier Source: org_study_id