Genetic Studies of Early-onset Dementia

NCT ID: NCT04906863

Last Updated: 2025-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-14

Study Completion Date

2028-04-30

Brief Summary

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The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Detailed Description

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The study population includes individuals affected by Alzheimer's Disease, mild cognitive impairment, other dementias, cognitively healthy individuals without memory problems, or their family members.

Ascertainment is across both males and females, and all race and ethnic groups.

Conditions

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Dementia, Early Onset

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Mild Cognitive Impairment

Individuals with mild cognitive impairment that began before age 70

Blood draw

Intervention Type GENETIC

Blood draw for identification of genetic variants associated with the development of memory problems

Neurocognitive testing

Intervention Type OTHER

Brief memory test

Medical questionnaire

Intervention Type OTHER

Collection of medical history

Dementia/Alzheimer's Disease

Individuals with Alzheimer's Disease or other dementia that began before age 70

Blood draw

Intervention Type GENETIC

Blood draw for identification of genetic variants associated with the development of memory problems

Neurocognitive testing

Intervention Type OTHER

Brief memory test

Medical questionnaire

Intervention Type OTHER

Collection of medical history

Cognitively Healthy

Cognitively healthy individuals over the age of 30 years

Blood draw

Intervention Type GENETIC

Blood draw for identification of genetic variants associated with the development of memory problems

Neurocognitive testing

Intervention Type OTHER

Brief memory test

Medical questionnaire

Intervention Type OTHER

Collection of medical history

Interventions

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Blood draw

Blood draw for identification of genetic variants associated with the development of memory problems

Intervention Type GENETIC

Neurocognitive testing

Brief memory test

Intervention Type OTHER

Medical questionnaire

Collection of medical history

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years and older
* Individuals diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion Criteria

-Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Miami

OTHER

Sponsor Role collaborator

National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Columbia University

OTHER

Sponsor Role lead

Responsible Party

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Christiane Reitz, MD, PhD

Associate Professor of Neurology and Epidemiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christiane Reitz, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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Columbia University Irving Medical Center

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Pamela Del Rosario

Role: CONTACT

212-304-7284

Facility Contacts

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Pamela del Rosario, MD

Role: primary

212-304-7284

Other Identifiers

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5U24AG056270-07

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1R01AG064614

Identifier Type: NIH

Identifier Source: secondary_id

View Link

AAAQ9793

Identifier Type: -

Identifier Source: org_study_id

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