Genetics of Recurrent Early Onset Major Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2302 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-10-31

Study Completion Date

2009-06-30

Brief Summary

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This study will identify specific genes that may cause a predisposition to depression in some families.

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Detailed Description

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Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression.

Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study.

For information on a related study please follow this link:

http://clinicaltrials.gov/show/NCT00005914

Conditions

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Depression

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* History of recurrent major depression
* Has a parent or sibling with a history of recurrent major depression
* Depression began before the age of 31

Exclusion Criteria

* Bipolar I (manic-depressive) disorder
* Schizophrenia

Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Douglas F. Levinson

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Douglas F. Levinson, MD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Myrna M. Weissman, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University/New York State Psychiatric Institute

J. Raymond DePaulo, MD

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

William A. Scheftner, MD

Role: PRINCIPAL_INVESTIGATOR

Rush University Medical Center

William Coryell, MD

Role: PRINCIPAL_INVESTIGATOR

University of Iowa

William Lawson, MD

Role: PRINCIPAL_INVESTIGATOR

Howard University

Locations

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Stanford University

Palo Alto, California, United States

Site Status

Howard University

Washington D.C., District of Columbia, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

University of Iowa

Iowa City, Iowa, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

Columbia University/New York State Psychiatric Institute

New York, New York, United States

Site Status

Countries

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United States