Genetics of Recurrent Early-Onset Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2533 participants

Study Classification

OBSERVATIONAL

Study Start Date

1999-10-31

Study Completion Date

2005-10-31

Brief Summary

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This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes.

More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments.

A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name).

Reimbursement is provided.

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Detailed Description

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Studies of patterns of major depression in families suggest that 50 to 70% of the predisposition to major depression is caused by genes. People with recurrent depression and earlier ages of onset have more relatives with depression. There are probably at least several interacting genes, rather than a single gene as in some disorders. The identification of predisposing genes is likely to lead to greater understanding of the brain mechanisms involved in severe depression. This could lead to the discovery of new treatments.

This study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study.

Participants in this study will be interviewed about psychiatric and family history, and will be asked for a small blood specimen. Interviews can be conducted in person or by telephone. For telephone interviews, blood sample collection will be arranged at a location and time convenient for the participant. Participants will also be asked for help in inviting other family members to participate. No family member will be contacted without the permission and assistance of another participating family member.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00260182

Conditions

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Depression

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

RETROSPECTIVE

Study Groups

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Probands and family members

Individuals with major depressive disorder who meet study criteria, and members of their families. No intervention. This is a genetic study only.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression.
* Depression must be RECURRENT (more than one episode).
* Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling.

Exclusion Criteria

* Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Douglas F. Levinson

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Myrna Weissman

Role: PRINCIPAL_INVESTIGATOR

Columbia University

J R DePaulo

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

William Scheftner

Role: PRINCIPAL_INVESTIGATOR

Rush University Hospital

Raymond Crowe

Role: PRINCIPAL_INVESTIGATOR

University of Iowa

Douglas Levinson

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

George Zubenko

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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Rush Presbyterian - Saint Luke's Med Ctr

Chicago, Illinois, United States

Site Status

Univ of Iowa Hosp and Clinic

Iowa City, Iowa, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

New York State Psychiatric Institute / Columbia Univ

New York, New York, United States

Site Status

Univ of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Univ of Pittsburgh / Western Psychiatric Inst and Clinic

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States