Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis

NCT ID: NCT04880187

Last Updated: 2022-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

273 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-07

Study Completion Date

2023-10-31

Brief Summary

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This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis in subjects with non alcoholic steatohepatitis (NASH). as well as the safety and tolerability of AXA1125. Subjects will take one of two different doses of AXA1125 or a placebo twice daily, and a liver biopsy will be done at the beginning and end of the 48-week study.

Detailed Description

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Conditions

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Non Alcoholic Steatohepatitis (NASH)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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AXA1125 22.6g

22.6 g AXA1125 administered orally BID with or without food

Group Type EXPERIMENTAL

AXA1125

Intervention Type DRUG

AXA1125 administered BID with or without food

AXA1125 33.9g

33.9 g AXA1125 administered orally BID with or without food

Group Type EXPERIMENTAL

AXA1125

Intervention Type DRUG

AXA1125 administered BID with or without food

Placebo

Matching Placebo administered orally BID with or without food

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching Placebo administered BID with or without food

Interventions

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AXA1125

AXA1125 administered BID with or without food

Intervention Type DRUG

Placebo

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Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Willing to participate in the study and provide written informed consent.
* Male and female adults aged \> 18 years.
* Must have NASH and fibrosis on a liver biopsy sample
* If a historical liver biopsy is used for Screening, obtained within 6 months prior to Screening;
* Subjects may have a diagnosis of T2DM

Exclusion Criteria

* History or presence of liver disease (other than NAFLD or NASH)
* History or presence of cirrhosis and/or history or presence of hepatic decompensation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Axcella Health, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stephen Harrison, MD

Role: PRINCIPAL_INVESTIGATOR

Pinnacle Clinical Research

Locations

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Cullman Clinical Trials

Cullman, Alabama, United States

Site Status RECRUITING

Adobe Clinical Research, LLC

Tucson, Arizona, United States

Site Status RECRUITING

Del Sol Research Management, LLC

Tucson, Arizona, United States

Site Status RECRUITING

San Fernando Valley Health Institute

Canoga Park, California, United States

Site Status RECRUITING

National Research Institute

Gardena, California, United States

Site Status RECRUITING

National Research Institute

Huntington Park, California, United States

Site Status RECRUITING

OM Research LLC

Lancaster, California, United States

Site Status RECRUITING

National Research Institute

Los Angeles, California, United States

Site Status RECRUITING

Inland Empire Liver Foundation

Rialto, California, United States

Site Status RECRUITING

Precision Research Institute, LLC

San Diego, California, United States

Site Status RECRUITING

Excel Medical Clinical Trials, LLC

Boca Raton, Florida, United States

Site Status RECRUITING

Synergy Healthcare

Bradenton, Florida, United States

Site Status RECRUITING

Tampa Bay Medical Research , Inc.

Clearwater, Florida, United States

Site Status RECRUITING

Evolution Clinical Trials, Inc.

Hialeah Gardens, Florida, United States

Site Status RECRUITING

Westside Center for Clinical Research

Jacksonville, Florida, United States

Site Status RECRUITING

ENCORE Borland Groover Clinical Research

Jacksonville, Florida, United States

Site Status RECRUITING

ClinCloud LLC

Maitland, Florida, United States

Site Status RECRUITING

Clinical Pharmacology of Miami, LLC

Miami, Florida, United States

Site Status RECRUITING

La Salud Research

Miami, Florida, United States

Site Status RECRUITING

Genoma Research Group, Inc

Miami, Florida, United States

Site Status RECRUITING

Panax Clinical Research

Miami Lakes, Florida, United States

Site Status RECRUITING

Sensible Healthcare, LLC

Ocoee, Florida, United States

Site Status RECRUITING

Theia Clinical Research, LLC

Pinellas Park, Florida, United States

Site Status RECRUITING

Progressive Medical Research

Port Orange, Florida, United States

Site Status RECRUITING

ClinCloud, LLC

Viera, Florida, United States

Site Status RECRUITING

Metabolic Research Institute, Inc.

West Palm Beach, Florida, United States

Site Status RECRUITING

Conquest Research

Winter Park, Florida, United States

Site Status RECRUITING

ASHA Clinical Research

Hammond, Indiana, United States

Site Status RECRUITING

Indiana University (IU) School of Medicine

Indianapolis, Indiana, United States

Site Status RECRUITING

Delta Research Partners

Bastrop, Louisiana, United States

Site Status RECRUITING

Tandem Clinical Research

Marrero, Louisiana, United States

Site Status RECRUITING

Tandem Clinical Research GI

Metairie, Louisiana, United States

Site Status RECRUITING

Louisiana Research Center, LLC

Shreveport, Louisiana, United States

Site Status RECRUITING

The National Diabetes & Obesity Research Institute

Biloxi, Mississippi, United States

Site Status RECRUITING

Jubilee Clinical Research, Inc.

Las Vegas, Nevada, United States

Site Status RECRUITING

Sierra Clinical Research

Las Vegas, Nevada, United States

Site Status RECRUITING

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status RECRUITING

Tandem Clinical Research GI

New York, New York, United States

Site Status RECRUITING

Lucas Research - Diabetes & Endocrinology Consultants, PC

Morehead City, North Carolina, United States

Site Status RECRUITING

Consultants for Clinical Research

Cincinnati, Ohio, United States

Site Status RECRUITING

Rapid City Medical Center

Rapid City, South Dakota, United States

Site Status RECRUITING

ClinSearch LLC

Chattanooga, Tennessee, United States

Site Status RECRUITING

Texas Clinical Research Institute

Arlington, Texas, United States

Site Status RECRUITING

American Research Corporation

Austin, Texas, United States

Site Status RECRUITING

Pinnacle Clinical Research

Austin, Texas, United States

Site Status RECRUITING

Pioneer Research Solutions Inc.

Houston, Texas, United States

Site Status RECRUITING

R & H Clinical Research

Katy, Texas, United States

Site Status RECRUITING

EPIC Medical Research

Red Oak, Texas, United States

Site Status RECRUITING

American Research Corporation

San Antonio, Texas, United States

Site Status RECRUITING

Endeavor Clinical Trials

San Antonio, Texas, United States

Site Status RECRUITING

Pinnacle Clinical Research

San Antonio, Texas, United States

Site Status RECRUITING

R & H Clinical Research

Stafford, Texas, United States

Site Status RECRUITING

Simcare Medical Research, LLC

Sugar Land, Texas, United States

Site Status RECRUITING

Impact Clinical Research

Waco, Texas, United States

Site Status RECRUITING

Velocity - Advanced Clinical Research - Salt Lake City of Gastroenterolog

Riverton, Utah, United States

Site Status RECRUITING

Manassas Clinical Research Center

Manassas, Virginia, United States

Site Status RECRUITING

Virginia Commonwealth University Medical College of Virginia

Richmond, Virginia, United States

Site Status RECRUITING

Flinders Medical Centre

Bedford Park, , Australia

Site Status RECRUITING

Royal Brisbane and Women's Hospital

Brisbane, , Australia

Site Status RECRUITING

Monash Medical Centre

Clayton, , Australia

Site Status RECRUITING

Concord Repatriation General Hospital

Concord, , Australia

Site Status RECRUITING

Fiona Stanley Hospital

Murdoch, , Australia

Site Status RECRUITING

University of Calgary Liver Unit

Calgary, Alberta, Canada

Site Status RECRUITING

LMC Diabetes & Endocrinology Ltd

London, Ontario, Canada

Site Status RECRUITING

Toronto Liver Centre

Toronto, Ontario, Canada

Site Status RECRUITING

Nova Scotia Health Authority

Halifax, , Canada

Site Status RECRUITING

CHU Grenoble-Alpes - Hopital Michallon

La Tronche, , France

Site Status RECRUITING

Hôpital de la Croix Rousse - HCL

Lyon, , France

Site Status RECRUITING

CHU de Montpellier - Hopital Saint Eloi

Montpellier, , France

Site Status RECRUITING

AP-HP Hopital Saint Antoine

Paris, , France

Site Status RECRUITING

CHU Bordeaux - Hopital Haut-Leveque

Pessac, , France

Site Status RECRUITING

AP-HP Hopital Paul Brousse

Villejuif, , France

Site Status RECRUITING

ID Clinic

Mysłowice, CET, Poland

Site Status RECRUITING

Fundacion de Investigacion (FDI)

San Juan, , Puerto Rico

Site Status RECRUITING

King's College Hospital

London, , United Kingdom

Site Status RECRUITING

Countries

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United States Australia Canada France Poland Puerto Rico United Kingdom

Central Contacts

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Margaret Koziel, MD

Role: CONTACT

(857) 320-3200

Other Identifiers

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AXA1125-101

Identifier Type: -

Identifier Source: org_study_id

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