Effects of Espresso on Platelet Aggregability in Patients with Coronary Artery Disease
NCT ID: NCT04827251
Last Updated: 2025-02-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
29 participants
INTERVENTIONAL
2022-09-01
2024-11-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Caffeinated coffee
Patients will be instructed to abstain from caffeinated beverages during 22 days. After this period, they will consume caffeinated coffee during 28 days, followed by decaffeinated coffee during more 28 days.
Coffee
Participants will receive "Nespresso" coffee maker "Essenza" model. The coffee "Nespresso blend voluto" will be provided (caffeinated and decaffeinated). The patients will have to take four cups of espresso per day (three cups a day for patients aged 65 and over).
Decaffeinated coffee
Patients will be instructed to abstain from caffeinated beverages during 22 days. After this period, they will consume decaffeinated coffee during 28 days, followed by caffeinated coffee during more 28 days.
Coffee
Participants will receive "Nespresso" coffee maker "Essenza" model. The coffee "Nespresso blend voluto" will be provided (caffeinated and decaffeinated). The patients will have to take four cups of espresso per day (three cups a day for patients aged 65 and over).
Interventions
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Coffee
Participants will receive "Nespresso" coffee maker "Essenza" model. The coffee "Nespresso blend voluto" will be provided (caffeinated and decaffeinated). The patients will have to take four cups of espresso per day (three cups a day for patients aged 65 and over).
Eligibility Criteria
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Inclusion Criteria
* Coronary artery disease documented by coronary angiography;
* Use of aspirin 100mg.
Exclusion Criteria
* Hemoglobin \<12 g/% for men and \<11 g/% for women;
* Platelets \<100,000 or \>400,000/mm3;
* Leukocytosis \>12,000/mm3;
* Fasting glycemia \>126mg/dl;
* Aspartate aminotransferase (AST) and/or Alanine aminotransferase (ALT) with values above the upper limits of normality;
* Consumption of more than 30 grams of alcohol per day;
* Active smoking or ex-smoking for less than 2 years;
* Use of P2Y12 inhibitor;
* Ventricular dysfunction (left ventricular ejection fraction \<45%).
20 Years
80 Years
ALL
No
Sponsors
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Fundação de Amparo à Pesquisa do Estado de São Paulo
OTHER_GOV
University of Sao Paulo
OTHER
Responsible Party
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Jose Carlos Nicolau
Director of Coronary Care Unit
Locations
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Heart Institute (InCor) / University of São Paulo
São Paulo, São Paulo, Brazil
Countries
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References
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Adriana Farah. Coffee: Emerging Health Effects and Disease Prevention. Coffee Constituints. 2012. John Wiley & Sons, Inc. Published by Blackwell Publishing Ltd.
Greenberg JA, Chow G, Ziegelstein RC. Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). Am J Cardiol. 2008 Dec 1;102(11):1502-8. doi: 10.1016/j.amjcard.2008.07.046. Epub 2008 Sep 11.
Wu JN, Ho SC, Zhou C, Ling WH, Chen WQ, Wang CL, Chen YM. Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies. Int J Cardiol. 2009 Nov 12;137(3):216-25. doi: 10.1016/j.ijcard.2008.06.051. Epub 2008 Aug 15.
Lopez-Garcia E, van Dam RM, Willett WC, Rimm EB, Manson JE, Stampfer MJ, Rexrode KM, Hu FB. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation. 2006 May 2;113(17):2045-53. doi: 10.1161/CIRCULATIONAHA.105.598664. Epub 2006 Apr 24.
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Andersen LF, Jacobs DR Jr, Carlsen MH, Blomhoff R. Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study. Am J Clin Nutr. 2006 May;83(5):1039-46. doi: 10.1093/ajcn/83.5.1039.
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Olas B, Brys M. Effects of coffee, energy drinks and their components on hemostasis: The hypothetical mechanisms of their action. Food Chem Toxicol. 2019 May;127:31-41. doi: 10.1016/j.fct.2019.02.039. Epub 2019 Mar 4.
Natella F, Nardini M, Belelli F, Pignatelli P, Di Santo S, Ghiselli A, Violi F, Scaccini C. Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. Br J Nutr. 2008 Dec;100(6):1276-82. doi: 10.1017/S0007114508981459. Epub 2008 Apr 28.
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Other Identifiers
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SDC 4954/19/173
Identifier Type: -
Identifier Source: org_study_id
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