Impact of Hyperoxia and Involvement of the Immune System in Diving Accident
NCT ID: NCT04791488
Last Updated: 2023-04-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
265 participants
INTERVENTIONAL
2022-03-30
2028-03-30
Brief Summary
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In mammals, normoxic concentrations have been redefined at 20-100 mbars at the extracellular level and below 10 mbars in the mitochondria.
Under hyperbaric conditions, most of the oxygen being dissolved in blood plasma, a state of hyperoxia is established which escapes the usual delivery and regulation system represented by red blood cells.
The results of our team's previous work suggest a specific effect of diving on the levels of circulating mitochondrial DNA (mtDNA), suggesting cellular destruction linked to hyperoxia/hyperbaria. In fact, our studies, carried out on both animals and human divers, have shown that diving accident leads to an increase in mtDNA levels and an immune reaction through the mobilisation of leukocytes.
The main objective of this study is to compare the influence of oxygen partial pressure levels on the evolution of clinical and biological variables during hyperbaric oxygen therapy sessions in healthy versus injured divers.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Healthy individuals
Hyperbaric oxygen therapy
Hyperbaric oxygen therapy protocol
Diving simulation
Hyperbaric chamber diving simulation protocol
Decompression sickness patients
Hyperbaric oxygen therapy
Hyperbaric oxygen therapy protocol
Interventions
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Hyperbaric oxygen therapy
Hyperbaric oxygen therapy protocol
Diving simulation
Hyperbaric chamber diving simulation protocol
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Direction Centrale du Service de Santé des Armées
OTHER
Responsible Party
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Locations
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Hôpital d'Instruction des Armées Sainte-Anne
Toulon, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2019PBMD05
Identifier Type: -
Identifier Source: org_study_id
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