Postexercise Hot-Water Immersion on Exercise Performance in Hypoxia

NCT ID: NCT06672614

Last Updated: 2024-11-04

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-11-01
• Study Completion Date: 2025-10-31

Brief Summary

The purpose of this study is to determine the effect of 5 days post-exercise hot water immersion on exercise performance at simulated altitude.

Detailed Description

Human performance is compromised at altitude due to a lower partial pressure of oxygen and subsequent reductions in the convective transport of oxygen to tissue. Long-term acclimation to attitude incurs physiological adaptations that result in a near return to sea-level performance; however, the time required (~2 weeks) for such adaptations is often logistically challenging for athletes, military personnel or other individuals who reside at sea level. Recent research suggests that physiological acclimation to heat stress (i.e., heat acclimation) and altitude (i.e., hypoxia) share similar cellular adaptations, namely an up-regulation of Hypoxia-inducible factor 1 (HIF-1) and various heat shock proteins. Therefore, it is hypothesized that heat acclimation may provide physiological protection from reduced oxygen transport to the tissue and enhance performance at altitude. This cross-tolerance model is supported by traditional heat acclimation protocols (i.e., submaximal exercise in hot ambient temperature); however, it has not been tested with passive exposure to heat stress through post-exercise hot water immersion.

Conditions

Heat Exposure; Exercise Training

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Post-Exercise Hot Water Immersion

Participants will cycle for 60 minutes at 50% of maximal oxygen uptake (VO2 max) followed by 30 minutes post-exercise hot water immersion (40oC) for 5 consecutive days.

Group Type: EXPERIMENTAL

Post-Exercise Hot Water Immersion

Intervention Type: OTHER

Participants will cycle for 60 minutes at 50% of maximal oxygen uptake (VO2 max) followed by 30 minutes post-exercise hot water immersion (40oC) for 5 consecutive days.

Control group

Participants will cycle for 60 minutes at 50% of maximal oxygen uptake (VO2 max); however, there will be not water immersion following exercise.

Group Type: ACTIVE_COMPARATOR

Control Group

Intervention Type: OTHER

Participants will cycle for 60 minutes at 50% maximal oxygen uptake (VO2 max) for 5 consecutive days. There is no water immersion following the exercise.

Interventions

Post-Exercise Hot Water Immersion

Participants will cycle for 60 minutes at 50% of maximal oxygen uptake (VO2 max) followed by 30 minutes post-exercise hot water immersion (40oC) for 5 consecutive days.

Intervention Type: OTHER

Control Group

Participants will cycle for 60 minutes at 50% maximal oxygen uptake (VO2 max) for 5 consecutive days. There is no water immersion following the exercise.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Physically active (minimum of 90 minutes of moderate-intensity exercise per week)

Exclusion Criteria

• Cardiovascular disease
• resident of >1500 m above sea-level in the past year;
• history of fainting

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Nipissing University

OTHER

Sponsor Role: lead

Responsible Party

Geoff Hartley

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Geoffrey L Hartley, PhD

Role: PRINCIPAL_INVESTIGATOR

Nipissing University

Locations

Nipissing University

North Bay, Ontario, Canada

Countries

Canada

Central Contacts

Geoffrey L Hartley, PhD

Role: CONTACT

geoffh@nipissingu.ca

705 845-3887

Other Identifiers

NUREB # 103807

Identifier Type: -

Identifier Source: org_study_id