Cold Therapy in the Treatment of Exercise-induced Muscle Damage

NCT ID: NCT02341612

Last Updated: 2015-01-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 65 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-12-31
• Study Completion Date: 2014-08-31

Brief Summary

Subjects were randomly placed in five groups: (1) single exposure at 5°C in cold water immersion, (2) single exposure at 15°C in cold water immersion, (3) multiple exposures at 10°C in cold water immersion, (4) whole body cryotherapy (WBC) at 110°C and (5) passive recovery (control group). The single exposure groups performed cold water immersion immediately after exercise-induced muscle damage (EIMD) for 20 minutes. The multiple exposures group performed cold water immersion immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes. The WBC group remained in the cabin immediately after EIMD for 3 min. The control group was not exposed to treatment after the EIMD protocol. The subjects were asked to visit the laboratory on seven occasions. The first visit was the familiarization of the subjects with experimental procedures and their anthropometric assessment. One week after familiarization, on visit two, volunteers performed the exercise-induced muscle damage (EIMD) protocol and they were allocated to one of experimental groups. Indirect markers of muscle damage and inflammatory responses were evaluated at baseline (pre), immediately post, 24h, 48h, 72h, 96h, and 168h following the EIMD protocol by measuring anterior thigh muscle swelling, isometric knee extensors peak torque, knee extensors muscle soreness, countermovement vertical jump and blood sample analyzes.

Detailed Description

To avoid circadian influences, subjects were asked to visit the laboratory always at the same time of day. Volunteers were asked to not perform any vigorous physical activities or unaccustomed exercise during the experiment period. In addition, they were instructed not to intake medications or supplements during the study.

Conditions

Cryotherapy Effect

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

single exposure at 5°C in CWI

The subjects of this group performed cold water immersion (CWI) immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.

Group Type: EXPERIMENTAL

single exposure at 5°C in CWI

Intervention Type: OTHER

The subjects of this group performed cold water immersion immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.

single exposure at 15°C in CWI

The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.

Group Type: EXPERIMENTAL

single exposure at 15°C in CWI

Intervention Type: OTHER

The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.

multiple exposures at 10°C in CWI

The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.

Group Type: EXPERIMENTAL

multiple exposures at 10°C in CWI

Intervention Type: OTHER

The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.

whole body criotherapy (WBC)

The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.

Group Type: EXPERIMENTAL

whole body cryotherapy (WBC)

Intervention Type: OTHER

The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.

passive recovery

The control group was not exposed to treatment after the EIMD protocol.

Group Type: EXPERIMENTAL

passive recovery

Intervention Type: OTHER

The control group was exposed to treatment after the EIMD protocol.

Interventions

single exposure at 5°C in CWI

The subjects of this group performed cold water immersion immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.

Intervention Type: OTHER

single exposure at 15°C in CWI

The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.

Intervention Type: OTHER

multiple exposures at 10°C in CWI

The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.

Intervention Type: OTHER

whole body cryotherapy (WBC)

The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.

Intervention Type: OTHER

passive recovery

The control group was exposed to treatment after the EIMD protocol.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• College students were eligible for inclusion.

Exclusion Criteria

• A history of quadriceps muscle tear
• Neurological disease involving the lower limbs
• Current lower-limb musculoskeletal injury and thigh skinfold thickness >20 mm..
• Participants with potential vascular problems which cold therapy is contraindicated (eg, diagnoses of diabetes or Raynaud's disease) were also excluded

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

Sponsor Role: collaborator

University of Brasilia

OTHER

Sponsor Role: lead

Responsible Party

Angelina Freitas Siqueira

Angelina Freitas Siqueira

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Brasília

Brasília, Federal District, Brazil

Countries

Brazil

Other Identifiers

CEP/FS-UnB 234/13

Identifier Type: -

Identifier Source: org_study_id