Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
776684 participants
OBSERVATIONAL
2019-08-12
2020-01-21
Brief Summary
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Literature search will be performed using the Ovid Medline/PubMed database. Studies comparing the effect of hypothermia vs. normothermia at hospital admission on in-hospital mortality will be included in meta-analysis.
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Detailed Description
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Literature search will be conducted using the Ovid Medline/PubMed database. The search strategy will be based on the PICOS strategy.
Scientific articles reporting (1) accidental hypothermia in trauma patients overall or patients with TBI specifically, (2) body temperature and time of measurement, and (3) the impact of accidental hypothermia on outcomes will be included in the qualitative review.
Two meta-analyses will be performed including (1) trauma patients overall and (2) patients with TBI specifically. Studies reporting in-hospital mortality of hypothermic and normothermic trauma patients overall or patients with TBI specifically, based on the temperature measured at Emergency Department admission, will be included in meta-analysis. Meta-analysis will be performed using a Mantel-Haenszel random-effects model. The estimated effect size for mortality will be reported as odds ratio (OR) and 95% confidence interval (CI) for each study as well as for the overall cohort.
Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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Hypothermia group
Hypothermic trauma patients or hypothermic patients with traumatic brain injury specifically.
No interventions assigned to this group
Normothermia group
Normothermic trauma patients or normothermic patients with traumatic brain injury specifically.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* English language
* Study in trauma patients
* Reported body temperature and time of temperature measurement
* Reported impact of accidental hypothermia on outcomes
Exclusion Criteria
* Systematic reviews
* Articles on therapeutic hypothermia
ALL
No
Sponsors
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Insel Gruppe AG, University Hospital Bern
OTHER
Responsible Party
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Principal Investigators
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Tobias Haltmeier, MD
Role: PRINCIPAL_INVESTIGATOR
Inselspital, Bern University Hospital
Locations
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Inselspital, Bern University Hospial
Bern, , Switzerland
Countries
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Other Identifiers
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SRMA hypothermia trauma
Identifier Type: -
Identifier Source: org_study_id
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