Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
2925 participants
INTERVENTIONAL
2023-11-15
2023-12-30
Brief Summary
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Detailed Description
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The majority of adult cardiac arrest cases are associated with obstructive coronary artery disease. Thus, current guideline recommended that immediate angiography and primary revascularization in all patients with resuscitated cardiac arrest and ST-segment elevation on electrocardiography, and also in patients with resuscitated cardiac arrest without ST-segment elevation, but with high probability of acute coronary occlusion. However, even after prompt restoration of blood flow, a substantial proportion of patients with myocardial infarction (MI) experience extensive necrosis. The application of hypothermia in patients with acute MI focuses on the reducing energy consumption at cardiac level, a factor consistently linked to diminished infarction size in animal study. However, in a recent meta-analysis of randomized trials comparing different strategies for therapeutic hypothermia adjunctive to percutaneous coronary intervention (PCI) versus standard of care in patients with acute MI, faille to demonstrate clear benefit. It is important to note, however, these randomized trials were underpowered and as a results, they were unable to draw firm conclusions regarding the impact of therapeutic hypothermia.
Therefore, this study aimed to investigate the impact of therapeutic hypothermia on clinical outcomes in patients who underwent primary PCI for acute MI after OHCA.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Hypothermia
Patients admitted with out-of-hospital cardiac arrest and treated with hypothermia
Hypothermia
Patients admitted with out-of-hospital cardiac arrest and treated with hypothermia
No hypothermia
Patients admitted with out-of-hospital cardiac arrest and treated without hypothermia
No interventions assigned to this group
Interventions
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Hypothermia
Patients admitted with out-of-hospital cardiac arrest and treated with hypothermia
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Age \< 18 years
* Did not received primary PCI
* Hypothermia before CAG
* Obey mental status
18 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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SungA Bae
Clinical Professor
Principal Investigators
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Yongcheol Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Yongin Severance Hospital, Yonsei University College of Medicine
Locations
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Yongin Severance Hospitall, Yonsei University College of Medicine
Yongin, Gyeonggi-do, South Korea
Countries
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References
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Becker L, Gold LS, Eisenberg M, White L, Hearne T, Rea T. Ventricular fibrillation in King County, Washington: a 30-year perspective. Resuscitation. 2008 Oct;79(1):22-7. doi: 10.1016/j.resuscitation.2008.06.019. Epub 2008 Aug 6.
Berdowski J, Berg RA, Tijssen JG, Koster RW. Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies. Resuscitation. 2010 Nov;81(11):1479-87. doi: 10.1016/j.resuscitation.2010.08.006. Epub 2010 Sep 9.
Bobrow BJ, Spaite DW, Berg RA, Stolz U, Sanders AB, Kern KB, Vadeboncoeur TF, Clark LL, Gallagher JV, Stapczynski JS, LoVecchio F, Mullins TJ, Humble WO, Ewy GA. Chest compression-only CPR by lay rescuers and survival from out-of-hospital cardiac arrest. JAMA. 2010 Oct 6;304(13):1447-54. doi: 10.1001/jama.2010.1392.
Other Identifiers
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Door-to-cooling timing in OHCA
Identifier Type: -
Identifier Source: org_study_id
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