Influence of Therapeutic Hypothermia on Resting Energy Expenditure

NCT ID: NCT00500825

Last Updated: 2008-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-07-31

Study Completion Date

2008-05-31

Brief Summary

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The purpose of this study is the evaluation of the influence of therapeutic hypothermia on resting energy expenditure (REE) in patients after cardiopulmonary resuscitation (CPR). We hypothesized that hypothermia would reduce resting energy expenditure in these patients.

Detailed Description

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Therapeutic hypothermia improves neurologic outcome in patients after cardiopulmonary resuscitation (CPR) because of cardiac arrest. In the present study patients will be cooled to 33 degree Celsius after CPR for 24h. To avoid shivering patients will be analgosedated and medically paralysed. Analgosedation and relaxation have already shown to reduce oxygen consumption up to 20 % in critically ill patients.

In patients with brain injury, who were cooled to 33 degree Celsius using a cooling meadow REE could be significantly reduced. In critically ill patients with pyrexia cooling using a cooling meadow REE could be reduced. Oxygen consumption was reduced about 14,7% per degree Celsius.

So far no studies evaluating influence of therapeutic hypothermia on REE in patients after CPR have been published. Therefore we plan to measure REE in 25 cooled patients after CPR using indirect Calorimetry (Deltatrac II Metabolic Monitor, Datex Instrumentarium, Helsinki, Finland).

Conditions

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Cardiopulmonary Resuscitation

Keywords

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Cardiopulmonary resuscitation Therapeutic hypothermia resting energy expenditure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients successfully resuscitated after cardiac arrest undergoing therapeutic hypothermia

Measurement of Resting Energy Expenditure

Intervention Type PROCEDURE

Non-invasive measurement of Resting Energy Expenditure

Interventions

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Measurement of Resting Energy Expenditure

Non-invasive measurement of Resting Energy Expenditure

Intervention Type PROCEDURE

Other Intervention Names

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Deltatrac (Ohmeda)

Eligibility Criteria

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Inclusion Criteria

* St.p. CPR
* Indication for therapeutic hypothermia for 24h (33 degrees Celsius)

Exclusion Criteria

* Contraindication for therapeutic hypothermia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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Medical University of Vienna

Principal Investigators

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Ulrike Holzinger, MD

Role: PRINCIPAL_INVESTIGATOR

Medical University Vienna

Locations

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Medical University Vienna

Vienna, Vienna, Austria

Site Status

Countries

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Austria

References

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Holzinger U, Brunner R, Losert H, Fuhrmann V, Herkner H, Madl C, Sterz F, Schneeweiss B. Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest - a prospective observational cohort study. Crit Care. 2015 Mar 29;19(1):128. doi: 10.1186/s13054-015-0856-2.

Reference Type DERIVED
PMID: 25888299 (View on PubMed)

Other Identifiers

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486/2003

Identifier Type: -

Identifier Source: org_study_id