Cardiac ARrest : Brain OXymetry Depending on HYpothermia Depth

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-28

Study Completion Date

2017-03-09

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Cardiac arrest is a major public health problem, with 700 000 cases per year , and a survival ranging from 4 to 33%. The post- anoxic encephalopathy remains the most serious complication with only a third of survivors . It is due to a series of phenomena involving microcirculation disorders . Cerebral oximetry is a new technique to evaluate the microcirculatory status . To this day it is used in cardiovascular surgery at risk of cerebral hypoperfusion where desaturation of cerebral oximetry is synonymous with ischemia and microcirculatory disorders. Therapeutic hypothermia is the only treatment improves the outcome of patients after extra- hospital cardiac arrest resuscitation . Its mechanisms of action seem to change all the phenomena responsible for microcirculatory reperfusion disorders . Currently it is recommended to practice hypothermia between 32 and 34 ° C. However, a recent study suggests a superiority of hypothermia at 32 ° C rather than 34 ° C.

The hypothesis of this study is that cerebral oximetry value will be different in patients subjected to two different levels of therapeutic hypothermia in the aftermath of an extra- hospital cardiac arrest. These data allow a better understanding of the mechanisms underlying the benefit of this technique.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia

NCT03024021

Hypoxic-Ischemic Encephalopathy Post-Cardiorespiratory Arrest Coma Cardiac Arrest

COMPLETED

Oxidative Stress and Cardiac Arrest

NCT00888966

Heart Arrest

COMPLETED

Intra-arrest Therapeutic Hypothermia in Prehospital Cardiac Arrest

NCT00886184

Cardiac Arrest

COMPLETED NA

Accidental Hypothermia in Drowning-related OHCA

NCT05908630

Hypothermia, Accidental Hypothermia Due to Cold Environment Drowning +1 more

COMPLETED

Therapeutic Hypothermia After Cardiac Arrest in Non Shockable Rhythm

NCT01994772

Cardiac Arrest

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac Arrest

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

34°C

therapeutic hypothermia at 34 ° C

Group Type EXPERIMENTAL

therapeutic hypothermia at 34 ° C

Intervention Type PROCEDURE

32°C

therapeutic hypothermia at 32 ° C

Group Type EXPERIMENTAL

therapeutic hypothermia at 32 ° C

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

therapeutic hypothermia at 32 ° C

Intervention Type PROCEDURE

therapeutic hypothermia at 34 ° C

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient presented with an extra-hospital cardiac arrest resuscitation and to benefit from therapeutic hypothermia using a servo system to its temperature (CoolGard 3000 ® system)
* Age\> 18 years and \<80 years