Oxidative Stress and Cardiac Arrest

NCT ID: NCT00888966

Last Updated: 2011-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-04-30

Study Completion Date

2010-12-31

Brief Summary

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Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.

Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.

The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.

Detailed Description

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Conditions

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Heart Arrest

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Out of hospital cardiac arrest

Out of hospital cardiac patients successfully resuscitated and admitted to ICU

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Out of hospital cardiac arrest

Exclusion Criteria

* refractory shock
* moribund patient
* resuscitation \> 60 minutes
* hypothermia \< 30 degrees
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut d'Anesthesiologie des Alpes Maritimes

OTHER

Sponsor Role lead

Responsible Party

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CHU de Nice

Principal Investigators

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Carole Ichai, MD, PhD

Role: STUDY_CHAIR

Centre Hospitalier Universitaire de Nice

Locations

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CHU de Nice

Nice, , France

Site Status

Countries

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France

Other Identifiers

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IAAM 2009-2

Identifier Type: -

Identifier Source: org_study_id

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