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The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response

NCT ID: NCT00808925

Last Updated: 2013-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2013-07-31

Brief Summary

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There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.

Detailed Description

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Conditions

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"Exposure to Heat"

Keywords

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acclimation heat cytokines stress inflammation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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research arm

Group Type EXPERIMENTAL

exposure to heat

Intervention Type OTHER

Dressed in shorts and tennis shoes the subjects will be exposed to exercise-heat stress for 12 consecutive days (excluding Saturday). Daily exposure will last 120 min, under the controlled environmental conditions of 40oC and 40% relative humidity. The exercise will consist of walking on a treadmill at a pace of 5km/h and 2% incline.

Interventions

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exposure to heat

Dressed in shorts and tennis shoes the subjects will be exposed to exercise-heat stress for 12 consecutive days (excluding Saturday). Daily exposure will last 120 min, under the controlled environmental conditions of 40oC and 40% relative humidity. The exercise will consist of walking on a treadmill at a pace of 5km/h and 2% incline.

Intervention Type OTHER

Other Intervention Names

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acclimation to heat

Eligibility Criteria

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Inclusion Criteria

* age:18-25
* medically screened (healthy)

Exclusion Criteria

* BMI over 22 kg/m2
* systolic blood pressure over 120 mmHg
* any febrile illness during the last week preceding the study
* any skin disease
* diabetes
* any heart conditions.
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Medical Corps, Israel Defense Force

OTHER

Sponsor Role collaborator

Prof. Yoram Epstein

OTHER_GOV

Sponsor Role lead

Responsible Party

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Prof. Yoram Epstein

Heller institue, Sheba Medical Center

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Daniel S Moran, PhD

Role: STUDY_DIRECTOR

Institute of Military Physiology, IDF Medical Corps

Locations

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Heller Institute of Medical Reachearch, Sheba Medical Center

Tel Litwinsky, , Israel

Site Status

Countries

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Israel

Other Identifiers

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SHEBA-08-5524-YE-CTIL

Identifier Type: -

Identifier Source: org_study_id