Depression, Anxiety and Social Relationships as Risk Factors for Dementia

NCT ID: NCT04786561

Last Updated: 2024-03-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 11000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-01-01
• Study Completion Date: 2024-01-01

Brief Summary

The main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. This risk factors, and efforts to reduce them are described through a follow up over three decades.

Detailed Description

The Health Study in Nord-Trondelag (HUNT) fulfils most of the key requirements of a population-representative cohort study by meeting the following elements: firm knowledge about the population denominator, knowledge about reasons for refusal (in line with previous methods in HUNT), options for levels and localisation of participation (at test station, at home, at nursing homes), coverage of sociodemographic features by the comprehensive HUNT4-protocol and register linkage, inclusion of institutionalized individuals and individuals with reduced capacity to consent, measurement of risk and compensatory factors across the life course by merging with previous results in HUNT surveys and linkage to registries, core elements and assessment methods can be compared with other European populations studies including elderly people, and finally, the ability to include biobank results in the data analysis. The HUNT data supplemented by register linkage include all established and suspected risk factors of dementia.

A particular focus on primary health care is appropriate because it is in this part of the health care system that the need for extra resources due to the substantial increase in dementia prevalence is most pronounced. Furthermore, preventive measures in a life-course perspective will mainly have to be implemented in the primary health care setting.

Conditions

Dementia; Dementia Alzheimers; Risk Factor; Depression; Anxiety; Social Isolation; Loneliness

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

HUNT4 70+

All inhabitants of Nord-Trøndelag 70 years or older were invited to participate in HUNT 4 70+. HUNT4 refers to the fourth wave of the HUNT-study (HelseUndersøkelse i Nord-Trøndelag or health survey in northern part of Trøndelag community in Middle of Norway) and 70+ refers to the part of the survey directed to participants aged seventy years and older.

No interventions assigned to this group

HUNT4 70+ Trondheim

All inhabitants of one district in Trondheim 70 years or older were invited to participate in HUNT 4 70+

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Living in designated area

Exclusion Criteria

• None

• Minimum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Norwegian Health Association

OTHER

Sponsor Role: collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role: collaborator

Norwegian Institute of Public Health

OTHER_GOV

Sponsor Role: collaborator

University College, London

OTHER

Sponsor Role: collaborator

Norwegian Centre for Ageing and Health

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Geir Selbæk, Phd

Role: PRINCIPAL_INVESTIGATOR

Norwegian National Advisory Unit on Ageing and Health

Locations

Norwegian national advisory unit on Ageing and Health

Tønsberg, , Norway

Countries

Norway

References

Aunsmo RH, Strand BH, Bergh S, Hansen T, Kivimaki M, Kohler S, Krokstad S, Langballe EM, Livingston G, Matthews FE, Selbaek G. Loneliness trajectories and dementia risk: Insights from the HUNT cohort study. Alzheimers Dement (Amst). 2025 Jul 29;17(3):e70154. doi: 10.1002/dad2.70154. eCollection 2025 Jul-Sep.

Reference Type: DERIVED

PMID: 40735047 (View on PubMed)

Other Identifiers

181011

Identifier Type: -

Identifier Source: org_study_id