Alinity m HR HPV Specimen Collection Study From Women Undergoing Routine Cervical Cancer Screening

NCT ID: NCT04746872

Last Updated: 2024-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

14935 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-16

Study Completion Date

2022-11-03

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A prospective multicenter interventional study will be conducted to enroll women undergoing routine cervical cancer screening to collect cervical liquid-based cytology (LBC) specimen(s). For all subjects, two cervical specimens will be collected, and one placed into Hologic ThinPrep Pap Test collection kit with PreservCyt Solution (also referred to as ThinPrep specimen) and the other into BD SurePath liquid-based Pap test (also referred to as SurePath specimen). Cytology and HR HPV results will be generated and utilized to determine need for subject referral to colposcopy. Collection of an endocervical curettage (ECC) specimen, and biopsy(ies) if applicable, from women who are referred to colposcopy as a follow up will be conducted according to a standardized protocol. Disease status for each subject will be determined based on cytology, HPV test results, and/or consensus histology review of cervical biopsy specimens.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Human Papillomavirus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Alinity m HR HPV

The Alinity m HR HPV IUO assay is a qualitative in vitro test that amplifies and detects HR HPV DNA in cervical cells collected in liquid media. The assay can differentiate between HPV 16, HPV 18, HPV 45 and non-HPV 16/18/45 genotypes \[(31/ 33/ 52/ 58) and (35/ 39/ 51/ 56/ 59/ 66/ 68)\].

Alinity m HR HPV

Intervention Type DIAGNOSTIC_TEST

A qualitative in vitro test that amplifies and detects HR HPV DNA in cervical tissue samples.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Alinity m HR HPV

A qualitative in vitro test that amplifies and detects HR HPV DNA in cervical tissue samples.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Women is eligible if she meets the following:

* Is 25 years of age or older
* Is attending a participating clinic for routine cervical cancer screening following screening guidelines
* Has an intact cervix
* Is willing and able to provide documented informed consent
* Is willing and able to undergo colposcopy, biopsy, and endocervical curettage (ECC) within 12 weeks (≤ 84 days) from the baseline visit, if required
* Is willing and able to allow collection of two cervical cytology specimens

Exclusion Criteria

A women is ineligible for the study if she meets any of the following criteria:

* Is pregnant at the time of visit or plans to become pregnant within the following 12 weeks
* Has any known medical condition that, in the opinion of the investigator, would result in increased risk of bleeding at biopsy
* Has a known history of excisional or ablative therapy (e.g., LEEP, cone biopsy, cervical laser surgery, or cryotherapy) to the cervix in the last 12 months prior to the baseline visit
* Had a cervical cytology specimen collected within the last 4 months
* Is currently participating in any diagnostic trial for cervical cancer
* Had a complete or partial hysterectomy, either supra cervical or involving removal of the cervix
* Is currently participating or planning to participate in any clinical trial for HPV treatment (for the duration of this study)
* Previous participation in this study
Minimum Eligible Age

25 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Abbott Molecular

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Alabama at Birmingham Hospital

Birmingham, Alabama, United States

Site Status

MedPharmics, LLC

Phoenix, Arizona, United States

Site Status

Desert Bloom Family Medicine / West Valley Research Clinic, LLC

Phoenix, Arizona, United States

Site Status

Quality of Life Medical & Research Centers, LLC

Tucson, Arizona, United States

Site Status

Visions Clinical Research

Tucson, Arizona, United States

Site Status

Northern California Research

Sacramento, California, United States

Site Status

Physicians' Research Options

Lakewood, Colorado, United States

Site Status

Planned Parenthood of Southern New England

New Haven, Connecticut, United States

Site Status

David I Lubetkin, MD, LLC

Boca Raton, Florida, United States

Site Status

Health Awareness INC

Jupiter, Florida, United States

Site Status

Health Awareness, Inc.

Jupiter, Florida, United States

Site Status

Partners in Womens Health of Jupiter, LLC

Jupiter, Florida, United States

Site Status

Altus Research

Lake Worth, Florida, United States

Site Status

South Florida Clinical Research

Margate, Florida, United States

Site Status

South Miami OB-GYN, Associates, LLC

Miami, Florida, United States

Site Status

Health Awareness, Inc.

Port Saint Lucie, Florida, United States

Site Status

Physician Care Clinical Research LLC

Sarasota, Florida, United States

Site Status

Joyce R. Miller, MD, LLC dba South Miami Womens Health an Elligo Health Research Site

South Miami, Florida, United States

Site Status

Comprehensive Clinical Trials, LLC

West Palm Beach, Florida, United States

Site Status

Soapstone Center For Clinical Research

Decatur, Georgia, United States

Site Status

The Women's Clinic

Boise, Idaho, United States

Site Status

Clinical Research Prime

Idaho Falls, Idaho, United States

Site Status

Leavitt Women's Healthcare

Idaho Falls, Idaho, United States

Site Status

Providea Health Partners, LLC an Elligo Health Research Site

Mokena, Illinois, United States

Site Status

Women's Health Advantage

Fort Wayne, Indiana, United States

Site Status

Clinical Trials Management, LLC

Covington, Louisiana, United States

Site Status

MedPharmics, LLC

Covington, Louisiana, United States

Site Status

Newman Comprehensive Obgyn

Covington, Louisiana, United States

Site Status

MedPharmics, LLC

Metairie, Louisiana, United States

Site Status

NECCR Fall River LLC

Fall River, Massachusetts, United States

Site Status

Valley Ob-Gyn Clinic, PC and Elligo Health Research Site

Saginaw, Michigan, United States

Site Status

Saginaw Valley Medical Research Group

Saginaw, Michigan, United States

Site Status

Planned Parenthood MN-ND-SD

Saint Paul, Minnesota, United States

Site Status

MedPharmics

Gulfport, Mississippi, United States

Site Status

Meridian Clinical Research

Hastings, Nebraska, United States

Site Status

Women's Clinic of Lincoln, PC

Lincoln, Nebraska, United States

Site Status

Dr. Nader and Associates

Las Vegas, Nevada, United States

Site Status

Rex Garn Mabey

Las Vegas, Nevada, United States

Site Status

Capital Health - Lawrence Ob-Gyn Associates PC

Lawrenceville, New Jersey, United States

Site Status

Carolina Institute for Clinical Research

Fayetteville, North Carolina, United States

Site Status

Eastern Carolina Women's Center

New Bern, North Carolina, United States

Site Status

Unified Women's Clinical Research -Raleigh

Raleigh, North Carolina, United States

Site Status

Unified Women's Clinical Research- Lyndhurst Clinical Research

Winston-Salem, North Carolina, United States

Site Status

Cleveland MacDonald Women's Hospital

Cleveland, Ohio, United States

Site Status

Hilltop Obstetrics & Gynecology, Inc.

Franklin, Ohio, United States

Site Status

The Ohio State University Obstetrics and Gynecology Worthington

Worthington, Ohio, United States

Site Status

The Ohio State University Obstetrics and Gynecology Worthington

Worthington, Ohio, United States

Site Status

OB GYN Associates of Erie

Erie, Pennsylvania, United States

Site Status

VitaLink Research - Greenville

Greenville, South Carolina, United States

Site Status

Tribe Clinical Research dba Mountain View Clinical Research

Greer, South Carolina, United States

Site Status

Medical Research Center of Memphis, LLC

Memphis, Tennessee, United States

Site Status

Women's Health Texas, LLC (Elligo)

Austin, Texas, United States

Site Status

Hill Country OB/GYN Associates

Austin, Texas, United States

Site Status

Austin Area Obgyn, PLLC

Austin, Texas, United States

Site Status

Christina Sebestyen MD, P.A. dba OBGYN North

Austin, Texas, United States

Site Status

Nueces County Women's Clinic dba Corpus Christi Women's Clinic an Elligo Health Research Site

Corpus Christi, Texas, United States

Site Status

Advanced Research Associates

Corpus Christi, Texas, United States

Site Status

Ventavia Research Group

Fort Worth, Texas, United States

Site Status

TMC Life Research, Inc.

Houston, Texas, United States

Site Status

Cedar Health Research, LLC_Avacare West

Irving, Texas, United States

Site Status

Medical Colleagues of Texas, LLP

Katy, Texas, United States

Site Status

Physicians Research Options

Draper, Utah, United States

Site Status

Tidewater Clinical Research Inc

Norfolk, Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

V560-02-20S07-01

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.