Clinical Evaluation of the APTIMA® HPV 16 18/45 Genotype Assay on the PANTHER® System

NCT ID: NCT01694875

Last Updated: 2012-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2012-11-30

Brief Summary

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The objective of the clinical study is to evaluate the AHPV-GT Assay using the PANTHER System in cervical cancer screening.

This objective will be accomplished in the ASC-US Study by evaluating the performance characteristics of the AHPV-GT Assay using the PANTHER System in a sample population of women with ASC-US Pap test results who were 21 years of age or older ("≥21 years of age") at the time of their Pap visit. For the Adjunct Study, this objective will be accomplished by evaluating the ability of the AHPV-GT Assay using the PANTHER System to identify women at increased risk of cervical disease in a sample population of women with negative (NILM)cytology results who were ≥30 years of age at the time of their Pap visit.

Detailed Description

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Conditions

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Human Papillomavirus Infection

Keywords

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cervix cancer HPV APTIMA

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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No Treatment

APTIMA HPV Assay

Intervention Type DEVICE

In Vitro Diagnostics Assay

Interventions

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APTIMA HPV Assay

In Vitro Diagnostics Assay

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Subjects who were previously enrolled into the prospective, multicenter US clinical study for the APTIMA HPV Assay on the TIGRIS System (protocol 2007HPVASCUS30) will be eligible for inclusion in the study of the AHPV-GT Assay using the PANTHER System described in this protocol. All evaluable ASC-US Study subjects ≥21 years of age will be eligible for inclusion.

Evaluable Adjunct Study subjects ≥30 years of age will be eligible if the following criteria are met:

* the subject attended the colposcopy visit, or
* the subject did not attend the colposcopy visit but the referral Pap sample had a positive APTIMA HPV Assay result in the APTIMA HPV Assay TIGRIS System study (protocol 2007HPVASCUS30) or in the APTIMA HPV Assay PANTHER System study (protocol AHPVPS-US11-003).

Exclusion Criteria

Eligible subjects will be excluded if they do not have an evaluable sample. This may be due to insufficient volume or because the sample was deemed unsuitable for testing (eg, stored under unacceptable conditions).
Minimum Eligible Age

21 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gen-Probe, Incorporated

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jennifer L Reid, PhD

Role: STUDY_DIRECTOR

Gen-Probe, Incorporated

Locations

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Hennepin County Medical Center

Minneapolis, Minnesota, United States

Site Status

Laboratory Corporation of America

Burlington, North Carolina, United States

Site Status

Molecular Pathology Laboratory Network, Inc

Maryville, Tennessee, United States

Site Status

Countries

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United States

Other Identifiers

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HPVGPS-US12-001

Identifier Type: -

Identifier Source: org_study_id