Epileptogenic Focus Localization for Children With Epilepsy Using 18F-FDG PET Molecular Imaging
NCT ID: NCT04725162
Last Updated: 2021-07-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
234 participants
OBSERVATIONAL
2014-07-01
2021-06-30
Brief Summary
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Detailed Description
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Pediatric patients with intractable epilepsy would be retrospectively included in this study. The inclusion criteria included (1) age between 6 and 18 y; (2) detailed seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/CT examination; (3) clinical diagnosis as focal epilepsy. The exclusion criteria included (a) any history of central nervous system disease; (b) poor image quality due to head movement.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Epilepsy patients
Pediatric patients with focal epilepsy.
18F-FDG
All subjects received 18F-FDG PET examination.
Control
Age-matched controls who underwent 18F-FDG PET/CT examination for diseases outside brains.
18F-FDG
All subjects received 18F-FDG PET examination.
Validation
Children who underwent 18F-FDG PET/MRI to examine extracranial tumors.
18F-FDG
All subjects received 18F-FDG PET examination.
Interventions
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18F-FDG
All subjects received 18F-FDG PET examination.
Eligibility Criteria
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Inclusion Criteria
* 2\. detailed presurgical evaluation, including seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/Computer Tomography (CT) examination.
* 3\. clinical diagnosis as focal epilepsy.
Exclusion Criteria
* 2\. poor image quality due to head movement.
6 Years
18 Years
ALL
No
Sponsors
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Second Affiliated Hospital, School of Medicine, Zhejiang University
OTHER
Responsible Party
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Locations
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Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Countries
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References
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Zhang T, Li Y, Zhao S, Xu Y, Zhang X, Wu S, Dou X, Yu C, Feng J, Ding Y, Zhu J, Chen Z, Zhang H, Tian M. High-resolution pediatric age-specific 18F-FDG PET template: a pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1560-1573. doi: 10.1007/s00259-021-05611-w. Epub 2021 Nov 8.
Other Identifiers
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2020-862
Identifier Type: -
Identifier Source: org_study_id
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