Mapping Epileptic Networks Using Multimodal Imaging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-14

Study Completion Date

2033-09-13

Brief Summary

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Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.

To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).

It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.

The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.

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Detailed Description

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Conditions

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Epilepsy in Children

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients

Secondary data collection

Intervention Type OTHER

clinical data

Interventions

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Secondary data collection

clinical data

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Be under 18 years of age on the day of inclusion.
* Present with one of the following forms of epilepsy:

* refractory focal lesional epilepsy
* rare non-lesional epilepsy
* Present abnormalities (spikes) on the intercritical EEG
* Have been selected by the "Epilepsy" multidisciplinary staff.
* In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
* Be affiliated to a health insurance scheme.

Exclusion Criteria

* Requiring general anesthesia for MRI
* Require sedation specifically for research
* Have generalized epilepsy
* Be deprived of liberty or under guardianship.

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No