PET/MRI/EEG Imaging Study in Epilepsy

NCT ID: NCT06974305

Last Updated: 2025-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-21

Study Completion Date

2025-11-30

Brief Summary

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This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Detailed Description

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Conditions

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Epilepsy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Healthy Controls

Healthy control subjects with no major medical history

FDG-PET/fMRI/EEG imaging

Intervention Type RADIATION

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Subjects with Epilepsy

Subjects diagnosed with epilepsy and with abnormal electrical activity recorded on interictal EEG.

FDG-PET/fMRI/EEG imaging

Intervention Type RADIATION

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Interventions

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FDG-PET/fMRI/EEG imaging

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Age 18 or older


* Diagnosed with epilepsy with abnormal interictal EEG

Exclusion Criteria

* Contraindications to PET, MRI, or EEG imaging
* History of severe brain disease such as stroke and head trauma
* History of brain surgery
* History of type I or II diabetes mellitus
* Fasting plasma glucose level \>200 mg/dL
* Employed under direct supervision of the PI conducting the research


* Current use of drugs that modulate brain function
* Current or past history of major medical, neurological, or psychiatric conditions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ciprian Catana, MD, PhD

Professor of Radiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ciprian Catana, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

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Athinoula A. Martinos Center

Charlestown, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Magdelena S Allen, BA

Role: CONTACT

617-724-9232

Facility Contacts

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Ciprian Catana

Role: primary

Other Identifiers

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2022P000929

Identifier Type: -

Identifier Source: org_study_id

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