Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
392 participants
OBSERVATIONAL
2018-12-01
2020-10-31
Brief Summary
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Detailed Description
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Patients underwent surgery for degenerative pathology of the spine independent of this study. After being informed about this study, all patients giving written informed consent who met eligibility requirements were included. Treatment of the patients was independent of this study. Intraoperative removed disc tissue was examined using microbiological culture, viral polymerase chain reaction (PCR), and histopathological analysis.
Other used data were demographic data (Gender, age), Modic Changes on MRI, preoperative Oswestry Disability Index (ODI), preoperative Neck Disability Index (NDI), and preoperative C-reactive protein (CRP).
Frequency of positive microbiological culture findings, viral PCR, and inflammation signs in histopathological analysis was described, and statistical analysis was performed to identify if any of the above mentioned parameters influences the frequency of positive microbiological culture and Modic Changes significant.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Routine discectomy
Patients undergoing routine spine surgery due to degenerative disease of the spine
Microbiological culture, viral PCR, histopathological analysis
Intervertebral disc tissue was sent to the laboratory for further analysis:
Microbiological culture: Detection of bacterial growth Viral PCR: Detection of Herpes-Simplex-Type 1 virus, Herpes-Simplex-Type 2 virus, Cytomegalovirus Histopathological analysis: Inflammation signs of disc tissue
Interventions
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Microbiological culture, viral PCR, histopathological analysis
Intervertebral disc tissue was sent to the laboratory for further analysis:
Microbiological culture: Detection of bacterial growth Viral PCR: Detection of Herpes-Simplex-Type 1 virus, Herpes-Simplex-Type 2 virus, Cytomegalovirus Histopathological analysis: Inflammation signs of disc tissue
Eligibility Criteria
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Inclusion Criteria
* Availability of removed disc tissue for further analysis
Exclusion Criteria
* Suspected or known tumor disease
* Traumatic fractures
18 Years
ALL
No
Sponsors
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Kepler University Hospital
OTHER
Responsible Party
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Principal Investigators
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Wolfgang Senker, MD
Role: PRINCIPAL_INVESTIGATOR
Kepler University Hospital
Locations
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Department of Neurosurgery, Kepler University Hospital
Linz, Upper Austria, Austria
Countries
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References
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Iyer S, Louie PK, Nolte MT, Phillips FM. The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data. J Am Acad Orthop Surg. 2019 Jul 15;27(14):509-518. doi: 10.5435/JAAOS-D-18-00257.
Stirling A, Worthington T, Rafiq M, Lambert PA, Elliott TS. Association between sciatica and Propionibacterium acnes. Lancet. 2001 Jun 23;357(9273):2024-5. doi: 10.1016/S0140-6736(00)05109-6. No abstract available.
Senker W, Aspalter S, Radl C, Pichler J, Doppler S, Weis S, Webersinke C, Wagner H, Hermann P, Aichholzer M, Aufschnaiter-Hiessbock K, Thomae W, Stroh N, Hauser T, Gruber A. Frequency and characteristics of bacterial and viral low-grade infections of the intervertebral discs: a prospective, observational study. J Orthop Traumatol. 2022 Mar 18;23(1):15. doi: 10.1186/s10195-022-00633-y.
Other Identifiers
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EK1078/2018
Identifier Type: -
Identifier Source: org_study_id
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