Study for Perioperative Neurocognitive Disorders After Deep Brain Stimulation Surgery for Parkinson's Disease

NCT ID: NCT04696978

Last Updated: 2021-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-08-01

Study Completion Date

2022-12-01

Brief Summary

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Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown. Metabolites could reveal chemical fingerprints left behind by cellular processes, which in turn provide a new aspect to understand the biological process behind. we aim to found the metabolomics can aid the development of diagnostic markers of PND screening, early detection, and further, provide a basis for disease prevention and treatment.

Detailed Description

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Conditions

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Neurocognitive Disorders

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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PND group

patients occur neurocognitive disorders according to scores in this group

No interventions assigned to this group

NO PND group

patients do not occur neurocognitive disorders according to scores in this group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Parkinson's patients undergoing elective deep brain stimulation
* Age ≥55 years
* ASA physical statusⅠ-Ⅲ
* Elementary school or above

Exclusion Criteria

* patients with ASA physical status\>III
* patients with systemic immune diseases, hematological diseases (hematological tumors or leukemia), patients after transplantation, malignant tumors
* patients with metabolic diseases such as diabetes, ketoacidosis, hyperosmolar syndrome, long-term hypoglycemia,gout
* patients who refused to join the study and lost to follow-up
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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wenbinlu

OTHER

Sponsor Role lead

Responsible Party

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wenbinlu

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Changhai Hospital, Second Military Medical University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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wenbin lu

Role: CONTACT

13004162573

jinjun bian, M.D

Role: CONTACT

13601963321

Facility Contacts

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jinjun bian, M.D

Role: primary

13601963321

Other Identifiers

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PND-PD

Identifier Type: -

Identifier Source: org_study_id

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