Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
NCT ID: NCT05933681
Last Updated: 2025-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
160 participants
INTERVENTIONAL
2023-07-06
2026-05-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SEQUENTIAL
BASIC_SCIENCE
NONE
Study Groups
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Determination of DLPFC neurophysiology biomarkers of DBS associated cognitive impairment
Neurophysiology recordings will be performed from dorsolateral prefrontal cortex (DLPFC) during deep brain stimulation surgery, with and without STN or GPI stimulation, at rest and during a working memory task.
Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
Neurophysiology biomarkers of DBS mediated cognitive impairment following chronic stimulation
Neurophysiology recordings will be performed from subthalamic nucleus (STN) or globus pallidus internus (GPI) with stimulation on and off, at rest and during a working memory task, in patients who have previously been implanted with DBS and have implantable pulse generators capable of recording local field potentials.
Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
Interventions
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Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
Eligibility Criteria
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Inclusion Criteria
* Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
* Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
* Age at least 18
* Able to participate in intraoperative testing
* English speaking
Exclusion Criteria
* Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
40 Years
ALL
No
Sponsors
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United States Department of Defense
FED
Vanderbilt University Medical Center
OTHER
Responsible Party
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Sarah Bick
Assistant Professor of Neurosurgery
Principal Investigators
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Sarah K Bick, MD
Role: PRINCIPAL_INVESTIGATOR
Vanderbilt University Medical Center
Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, United States
Countries
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Other Identifiers
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230539
Identifier Type: -
Identifier Source: org_study_id
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