Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

NCT ID: NCT01998204

Last Updated: 2013-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2013-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Parkinson's Disease

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Parkinson's disease propofol deep brain stimulator

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PD group

Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement

No interventions assigned to this group

non-PD group

Patients without Parkinson's disease undergoing intracranial surgery

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia
* non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia

Exclusion Criteria

* ASA score higher than Class III
* predicted difficult airway
* hearing impairment
* inability to corporate with instruction
* alcohol or drug abuser
* patients refusing to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Changhai Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Jia-feng Wang

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Jia-feng Wang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, Changhai Hospital, Second Military Medical University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Department of Anesthesiology, Changhai Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

References

Explore related publications, articles, or registry entries linked to this study.

Xu XP, Yu XY, Wu X, Hu XW, Chen JC, Li JB, Wang JF, Deng XM. Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study. Biomed Res Int. 2015;2015:953729. doi: 10.1155/2015/953729. Epub 2015 Oct 1.

Reference Type DERIVED
PMID: 26495319 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Parkinson-propofol

Identifier Type: -

Identifier Source: org_study_id