Wide Scale Monitoring for Acute Respiratory Infection Using a Mobile-Based Study Platform
NCT ID: NCT04663776
Last Updated: 2022-03-07
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Total Enrollment
16000 participants
Study Classification
OBSERVATIONAL
Study Start Date
2020-11-04
Study Completion Date
2021-12-08
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This is a prospective observational study using a mobile study platform (app) that is designed for use on Android phones. Study participants will provide baseline demographic and medical information and report symptoms of respiratory infection on a weekly basis using the app. Participants will also report use of prevention techniques on the weekly survey. Mobility data will be collected passively using the sensors on the participant's smartphone, if the participant has granted the proper device permissions. The overall goals of the study are to track spread of coronavirus-like illness (CLI), influenza-like illness (ILI) and non-specific respiratory illness (NSRI) on a near-real time basis and identify specific behaviors associated with an increased or decreased risk of developing these conditions.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Infection Watch Study
NCT04623047
COVID-19 Respiratory Infection
Respiratory Syncytial Virus Infections
Rhinoviral Infections
+1 more
COMPLETED
Birth Cohort Study for Respiratory Infections
NCT02361164
Upper Respiratory Tract Infections
COMPLETED
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
NCT04987840
Ventilator Associated Pneumonia
Tracheobronchitis
ENROLLING_BY_INVITATION
Early Identification and Severity Prediction of Acute Respiratory Infectious Disease
NCT04955756
Acute Respiratory Infection
Severe Pneumonia
Next Generation Sequencing
+1 more
UNKNOWN
NA
Surveillance of Influenza in Paediatric Intensive Care Units in Bavaria
NCT01286285
Influenza
Acute Respiratory Infection
UNKNOWN
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Covid19
Influenza
Respiratory Tract Infections
Acute Respiratory Tract Infection
Acute Respiratory Distress Syndrome
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Adult 18 years or older, Android mobile phone user, Resides in the United States (has a US home address)
Exclusion Criteria
* Under the age of 18, Does not use an Android mobile device, Opts out of sharing mobility data, Does not live within the United States
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Google LLC.
INDUSTRY
Sponsor Role
collaborator
Boston Children's Hospital
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
John Brownstein
Chief Innovation Officer
Responsibility Role
PRINCIPAL_INVESTIGATOR
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Boston Children's Hospital
Boston, Massachusetts, United States
Site Status
Countries
Review the countries where the study has at least one active or historical site.
United States
References
Explore related publications, articles, or registry entries linked to this study.
Thompson WW, Weintraub E, Dhankhar P, Cheng PY, Brammer L, Meltzer MI, Bresee JS, Shay DK. Estimates of US influenza-associated deaths made using four different methods. Influenza Other Respir Viruses. 2009 Jan;3(1):37-49. doi: 10.1111/j.1750-2659.2009.00073.x.
Reference Type
BACKGROUND
Molinari NA, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, Bridges CB. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007 Jun 28;25(27):5086-96. doi: 10.1016/j.vaccine.2007.03.046. Epub 2007 Apr 20.
Reference Type
BACKGROUND
Zhou H, Thompson WW, Viboud CG, Ringholz CM, Cheng PY, Steiner C, Abedi GR, Anderson LJ, Brammer L, Shay DK. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012 May;54(10):1427-36. doi: 10.1093/cid/cis211. Epub 2012 Apr 10.
Reference Type
BACKGROUND
Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, Li P, Zhou Y, Lin YF, Duan Q, Luo G, Fan S, Lu Y, Feng A, Zhan Y, Liang B, Cai W, Zhang L, Du X, Li L, Shu Y, Zou H. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect. 2020 Jun;80(6):656-665. doi: 10.1016/j.jinf.2020.03.041. Epub 2020 Apr 10.
Reference Type
BACKGROUND
Yee J, Unger L, Zadravecz F, Cariello P, Seibert A, Johnson MA, Fuller MJ. Novel coronavirus 2019 (COVID-19): Emergence and implications for emergency care. J Am Coll Emerg Physicians Open. 2020 Feb 22;1(2):63-69. doi: 10.1002/emp2.12034. eCollection 2020 Apr.
Reference Type
BACKGROUND
Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Jul;163(1):3-11. doi: 10.1177/0194599820926473. Epub 2020 May 5.
Reference Type
BACKGROUND
Kimball A, Hatfield KM, Arons M, James A, Taylor J, Spicer K, Bardossy AC, Oakley LP, Tanwar S, Chisty Z, Bell JM, Methner M, Harney J, Jacobs JR, Carlson CM, McLaughlin HP, Stone N, Clark S, Brostrom-Smith C, Page LC, Kay M, Lewis J, Russell D, Hiatt B, Gant J, Duchin JS, Clark TA, Honein MA, Reddy SC, Jernigan JA; Public Health - Seattle & King County; CDC COVID-19 Investigation Team. Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility - King County, Washington, March 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 3;69(13):377-381. doi: 10.15585/mmwr.mm6913e1.
Reference Type
BACKGROUND
Garg S, Kim L, Whitaker M, O'Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, Kawasaki B, Yousey-Hindes K, Niccolai L, Anderson EJ, Openo KP, Weigel A, Monroe ML, Ryan P, Henderson J, Kim S, Como-Sabetti K, Lynfield R, Sosin D, Torres S, Muse A, Bennett NM, Billing L, Sutton M, West N, Schaffner W, Talbot HK, Aquino C, George A, Budd A, Brammer L, Langley G, Hall AJ, Fry A. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):458-464. doi: 10.15585/mmwr.mm6915e3.
Reference Type
BACKGROUND
Schuchat A; CDC COVID-19 Response Team. Public Health Response to the Initiation and Spread of Pandemic COVID-19 in the United States, February 24-April 21, 2020. MMWR Morb Mortal Wkly Rep. 2020 May 8;69(18):551-556. doi: 10.15585/mmwr.mm6918e2.
Reference Type
BACKGROUND
Jefferson T, Del Mar C, Dooley L, Ferroni E, Al-Ansary LA, Bawazeer GA, van Driel ML, Foxlee R, Rivetti A. Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review. BMJ. 2009 Sep 21;339:b3675. doi: 10.1136/bmj.b3675.
Reference Type
BACKGROUND
Xiao J, Shiu EYC, Gao H, Wong JY, Fong MW, Ryu S, Cowling BJ. Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings-Personal Protective and Environmental Measures. Emerg Infect Dis. 2020 May;26(5):967-975. doi: 10.3201/eid2605.190994. Epub 2020 May 17.
Reference Type
BACKGROUND
Mateus AL, Otete HE, Beck CR, Dolan GP, Nguyen-Van-Tam JS. Effectiveness of travel restrictions in the rapid containment of human influenza: a systematic review. Bull World Health Organ. 2014 Dec 1;92(12):868-880D. doi: 10.2471/BLT.14.135590. Epub 2014 Sep 29.
Reference Type
BACKGROUND
Baltrusaitis K, Brownstein JS, Scarpino SV, Bakota E, Crawley AW, Conidi G, Gunn J, Gray J, Zink A, Santillana M. Comparison of crowd-sourced, electronic health records based, and traditional health-care based influenza-tracking systems at multiple spatial resolutions in the United States of America. BMC Infect Dis. 2018 Aug 15;18(1):403. doi: 10.1186/s12879-018-3322-3.
Reference Type
BACKGROUND
Bajardi P, Vespignani A, Funk S, Eames KT, Edmunds WJ, Turbelin C, Debin M, Colizza V, Smallenburg R, Koppeschaar CE, Franco AO, Faustino V, Carnahan A, Rehn M, Paolotti D. Determinants of follow-up participation in the Internet-based European influenza surveillance platform Influenzanet. J Med Internet Res. 2014 Mar 10;16(3):e78. doi: 10.2196/jmir.3010.
Reference Type
BACKGROUND
Wojcik OP, Brownstein JS, Chunara R, Johansson MA. Public health for the people: participatory infectious disease surveillance in the digital age. Emerg Themes Epidemiol. 2014 Jun 20;11:7. doi: 10.1186/1742-7622-11-7. eCollection 2014.
Reference Type
BACKGROUND
Smolinski MS, Crawley AW, Baltrusaitis K, Chunara R, Olsen JM, Wojcik O, Santillana M, Nguyen A, Brownstein JS. Flu Near You: Crowdsourced Symptom Reporting Spanning 2 Influenza Seasons. Am J Public Health. 2015 Oct;105(10):2124-30. doi: 10.2105/AJPH.2015.302696. Epub 2015 Aug 13.
Reference Type
BACKGROUND
Menni C, Valdes AM, Freidin MB, Sudre CH, Nguyen LH, Drew DA, Ganesh S, Varsavsky T, Cardoso MJ, El-Sayed Moustafa JS, Visconti A, Hysi P, Bowyer RCE, Mangino M, Falchi M, Wolf J, Ourselin S, Chan AT, Steves CJ, Spector TD. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med. 2020 Jul;26(7):1037-1040. doi: 10.1038/s41591-020-0916-2. Epub 2020 May 11.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
P00036213
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
The Fever Clinic Acute Respiratory Cohort
NCT07278700
RECRUITING
Prospective Evaluation of the Predictive Criteria of Severity for Respiratory Infection Due to COVID-19 Virus
NCT04615676
COMPLETED
Study of Viral Respiratory Infections
NCT06764381
NOT_YET_RECRUITING
A Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases
NCT05035420
COMPLETED
NA
Decreasing Unnecessary Antibiotics Prescribed for Possible Pneumonia Despite Normal Respiratory Rate and Oxygenation
NCT05172791
COMPLETED
NA
Lung Bacteriobiota and Influenza Mortality
NCT04131296
UNKNOWN
SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies
NCT05765396
ACTIVE_NOT_RECRUITING
Clinical Validation of the Aptitude Medical Systems Metrix Respiratory Panel Test in At-Home/Non-Laboratory Settings
NCT07217639
NOT_YET_RECRUITING
NA
Home Testing of Respiratory Illness
NCT04245800
COMPLETED
Audio Data Collection for Identification and Classification of Coughing
NCT04326309
COMPLETED
The COVID-19 Mobile Health Study (CMHS)
NCT04275947
UNKNOWN
Fast Identification of Pathogen in the Setting of Pneumonia Using Multiplex PCR
NCT01858974
COMPLETED
The DETECT(Digital Engagement & Tracking for Early Control, & Treatment) Study
NCT04336020
RECRUITING
Clinical Characteristics And Outcome Of COVID-19 Infection In Patients With Chronic Respiratory Diseases.
NCT05054127
UNKNOWN
Oxygen Requirements and Use in Patients With COVID-19 in LMICs
NCT04918875
UNKNOWN
Quantifying Viral Load in Respiratory Particles That Are Generated by Children and Adults With COVID-19 Infection
NCT05195229
UNKNOWN
NA
Impact on the Use of Antibiotics of a Multimodal Algorithm for the Diagnosis and Management of Acute Community-acquired Pneumonia in the Emergency Room
NCT05657275
COMPLETED
NA
A Pilot Study for the Collection Of Vocalized, Individual Digital Cough Sound Recordings to Screen for COVID-19
NCT04864535
UNKNOWN
Clinical Predictors of Severity in Pediatric Community-Acquired Pneumonia at Assiut University Children's Hospital
NCT07279675
NOT_YET_RECRUITING
FilmArray and Management of ICU Patients With Pneumonia in the Covid-19 Context
NCT04453540
UNKNOWN
Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study
NCT04365764
COMPLETED
Respiratory Aerosols in Patients With COVID-19 and Healthy Controls
NCT04739020
UNKNOWN
NA
Perspectives on Antibiotics and Tracking Symptoms in Children
NCT07093749
RECRUITING
NA
Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia
NCT03996967
COMPLETED
Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department
NCT02957136
COMPLETED
NA