Lung Bacteriobiota and Influenza Mortality

NCT ID: NCT04131296

Last Updated: 2019-11-01

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 64 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-12-01
• Study Completion Date: 2020-04-30

Brief Summary

Influenza is a potentially lethal disease still responsible for thousands excess deaths both in Europe and the United States. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. Lung microbiota has been shown to be involved in the immunity against influenza and is correlated with lung inflammation in numerous chronic respiratory diseases. We therefore aim to analyse the correlation between lung bacteriobiota and influenza ICU mortality

Detailed Description

Influenza is a viral disease which is still responsible for thousands of excess deaths par year both in Europe and in the US. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. As lung microbiota is correlated with lung inflammation in numerous chronic respiratory diseases, we hypothesize that lung microbiota would be correlated with influenza outcomes. In a pilot study, we found that lung bacteriobiota but not mycobiota is associated with influenza ICU mortality. We therefore aim to confirm this correlation between lung bacteriobiota and influenza mortality.

Conditions

Influenza; Critical Illness

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

influenza screening

positive influenza screening

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patient above 18 year-old admitted to intensive care unit
• Influenza diagnosis by PCR or rapid diagnostic test

Exclusion Criteria

• Guardianship or curatorship
• Prisoners
• No health insurance
• No legal representative

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Bordeaux

OTHER

Sponsor Role: lead

Responsible Party

Dr Pauline Esteves

Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Medical intensive care unit, Pellegrin hospital

Bordeaux, Nouvelle-Aquitaine, France

Intensive care unit, CH Robert Boulin

Libourne, , France

Intensive care unit, CH Francois Mitterrand

Pau, , France

Countries

France

Facility Contacts

Bernard Gauche, MD

Role: primary

bernard.gauche@ch-libourne.fr

Alexandre Massri, MD

Role: primary

alexandre.massri@ch-pau.fr

Other Identifiers

MicroFlu

Identifier Type: -

Identifier Source: org_study_id