Drug Resistance Factors In Healthcare-associated Pneumonia
NCT ID: NCT02736097
Last Updated: 2017-08-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
679 participants
OBSERVATIONAL
2016-11-30
2017-02-28
Brief Summary
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Detailed Description
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The HCAP categorization scheme is intended to improve the prescription of initial appropriate empiric antibacterial agents and minimize the morbidity and mortality associated with inappropriate empiric selection.However, one of the chief criticisms of the guideline recommendations is that the criteria used to define HCAP is overly broad, which may result in greater use of broad-spectrum antibiotics.
The prevailing notion is that many patients in the community will be at the lowest risk for experiencing MDR pneumonia and can be treated with a less broad anti-infective regimen. Patients with increasing exposure to the healthcare system will receive initial anti-infective therapy that is more broad in an effort to target MDROs. The investigator group believes that it is not simply exposure to the healthcare system that predicts the incidence of MDR pneumonia (i.e., criteria for HCAP), but rather, the "intensity" of exposure to the healthcare system that is predictive of MDR pneumonia. The aim of this study is to identify risk factors for MDR HCAP pneumonia in critically ill patients. .
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* ICU admission
* Empiric or directed anti-infective treatment for pneumonia for ≥ 5 days
Exclusion Criteria
* Patient transfer to the ICU from a hospital floor following prescription for anti-infective therapy in the previous 24 hours of ICU admission
* Diagnosis of cystic fibrosis or bronchiectasis
* Fungal pneumonia
18 Years
89 Years
ALL
No
Sponsors
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University of Arkansas
OTHER
Critical Care Pharmacotherapy Trials Network
OTHER
Responsible Party
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Ishaq Lat
Primary Investigator
Locations
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Hartford Healthcare
Hartford, Connecticut, United States
University of Florida - Jacksonville Hospital
Jacksonville, Florida, United States
Cleveland Clinic - Florida
Weston, Florida, United States
Memorial University Medical Center
Savannah, Georgia, United States
University of Chicago Medical Center
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Roudebush - Indianapolis Veterans Administration Hospital
Indianapolis, Indiana, United States
University of Kentucky Healthcare - Chandler Medical Center
Lexington, Kentucky, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Detroit Medical Center
Detroit, Michigan, United States
Spectrum Health
Grand Rapids, Michigan, United States
Beaumont Health System
Royal Oak, Michigan, United States
University of Minnesota - Fairview Health Services
Minneapolis, Minnesota, United States
Northeast Regional Medical Center
Kirksville, Missouri, United States
Lakes Regional General Healthcare
Laconia, New Hampshire, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
University of Rochester Medical Center
Rochester, New York, United States
Mercy Medical Center
Canton, Ohio, United States
Cleveland Clinic - Cleveland
Cleveland, Ohio, United States
Allegheny Health Network
Pittsburgh, Pennsylvania, United States
Roper St. Francis Healthcare
Charleston, South Carolina, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Seton Healthcare Family
Austin, Texas, United States
Memorial Hermann Healthcare System
Houston, Texas, United States
University of Wisconsin Hospital
Madison, Wisconsin, United States
Medical College of Wisconsin/ Froedtert Hospital
Milwaukee, Wisconsin, United States
Ministry of of National Guard-Health Affaires
Riyahd, , Saudi Arabia
Countries
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References
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Lat I, Daley MJ, Shewale A, Pangrazzi MH, Hammond D, Olsen KM; DEFINE study group and the Discovery Research Network. A Multicenter, Prospective, Observational Study to Determine Predictive Factors for Multidrug-Resistant Pneumonia in Critically Ill Adults: The DEFINE Study. Pharmacotherapy. 2019 Mar;39(3):253-260. doi: 10.1002/phar.2171. Epub 2018 Oct 3.
Other Identifiers
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15071001
Identifier Type: -
Identifier Source: org_study_id
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