The Fever Clinic Acute Respiratory Cohort

NCT ID: NCT07278700

Last Updated: 2025-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-10

Study Completion Date

2028-10-31

Brief Summary

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This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics. At enrollment, patients' clinical symptoms, laboratory findings, and chest imaging data will be collected. Longitudinal follow-up will be conducted to evaluate disease progression, complications, and long-term outcomes.

As an observational study, no interventions are involved; all patients receive routine clinical management as directed by their attending physicians. This real-world study design enables the assessment of the natural course of acute respiratory infections and the identification of factors associated with clinical outcomes.

Detailed Description

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This prospective cohort study aims to characterize the natural history and outcomes of acute respiratory infection in patients presenting to fever clinics. Upon enrollment, patients' clinical symptoms, laboratory parameters, and chest imaging data will be collected. Subsequent longitudinal follow-up will be performed to assess disease progression, complications, and long-term outcomes.

As an observational study, no interventions are implemented; all patients receive standard-of-care management as determined by their attending physicians. This real-world study design allows for the evaluation of the natural progression of acute respiratory infections and the identification of factors associated with clinical outcomes.

Conditions

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Acute Respiratory Infections Febrile Illnesses Community-acquired Pneumonia Viral Respiratory Tract Infections Influenza-like Illness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pneumonia Cohort

No intervention involved

Intervention Type OTHER

This is a observational study so no intervention involved.

Non-Pneumonia Cohort

No intervention involved

Intervention Type OTHER

This is a observational study so no intervention involved.

Interventions

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No intervention involved

This is a observational study so no intervention involved.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years (based on official identification document).
* Presence of fever at the time of visit or within 24 hours prior to the visit, defined as a documented temperature of ≥37.3°C axillary/tympanic, ≥37.8°C orally, or ≥38.0°C rectally.
* The primary cause of fever, as determined by the attending physician, is a respiratory tract infection.
* Blood draw is required as part of standard clinical care.
* Ability to comprehend the study's purpose, procedures, and potential risks, and willingness to provide written informed consent.

Exclusion Criteria

* Inability to provide independent informed consent due to impaired consciousness or other reasons.
* Inability to comply with the study procedures.
* Medical contraindications to blood sampling, such as severe coagulopathy (e.g., INR \> 3.0, platelet count \< 50 × 10⁹/L).
* Diagnosed with a terminal illness (e.g., advanced malignancy, severe multiple organ failure) and a life expectancy of less than 3 months.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Huadong Hospital

OTHER

Sponsor Role collaborator

Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Zhijun Bao

President

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Huadong hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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YingGang Zhu, Doctor

Role: CONTACT

+8618001637153

Facility Contacts

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XINQI LI

Role: primary

Other Identifiers

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FACTS

Identifier Type: -

Identifier Source: org_study_id

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