Neurological and Psychological Effects of Combat-Related Stress

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-01

Study Completion Date

2025-05-01

Brief Summary

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The purpose of this study is to determine what is the neurological and cognitive impact of combat exposure and prolonged stress, in the form of service in the Israeli Defense Forces.

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Detailed Description

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Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. This study aimed to characterize the mental resilience of combat soldiers, and explore the neuro-cognitive impact of prolonged stress, using eye-tracking, MRI and fMRI measurements. Participants will be assessed using questionnaires, cognitive tasks and magnetic imaging at 5 timepoints over the span of 4 years. Outcome measures will be depression, anxiety and post-traumatic scores, as well as dwell time on threat in eye-tracking paradigms tested in previous studies, and blood oxygen level-dependent (BOLD) signals in magnetic resonance imaging (MRI) measurements.

Conditions

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Stress Disorder, Posttraumatic Stress, Psychological

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Soldiers

50 Israeli Defense Forces (IDF) infantry soldiers, all male, aged 18 years, with Hebrew as the dominant language and no condition excluding an MRI scan.

Combat Exposure

Intervention Type OTHER

Soldiers will be exposed to combat as part of their routine military service. The ROTC students will not be exposed to combat.

Students

50 Reserve Officer Training Corps (ROTC) undergraduate students at Tel-Aviv University, all male, aged 18-19, with Hebrew as the dominant language and no condition excluding an MRI scan.

No interventions assigned to this group

Interventions

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Combat Exposure

Soldiers will be exposed to combat as part of their routine military service. The ROTC students will not be exposed to combat.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Soldiers in the paratroopers brigade or students in Tel-Aviv University;
* A signed consent form;
* Hebrew native speakers.

Exclusion Criteria

* A diagnosis of a neurological disorder (i.e., epilepsy, brain injury);
* Drug or alcohol abuse;
* Cannot undergo an MRI scan, due to metal implants or other metallic foreign bodies, claustrophobia, large tattoos or irremovable piercings;
* Require glasses with a number greater than 7;
* A diagnosis of psychotic or bipolar disorders.

Minimum Eligible Age

18 Years

Maximum Eligible Age

23 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No