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Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function

NCT ID: NCT01644851

Last Updated: 2014-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2015-07-31

Brief Summary

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The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.

Detailed Description

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Many posttraumatic stress disorder (PTSD) patients either choose not to complete or do not achieve optimal response to current first-line behavioral and pharmacologic treatments. Neurocognitive research points to the potential of novel treatments targeting dorsal prefrontal function and inhibition, attention, and working memory processes. This study investigates effects of computer-based training in executive functions compared to word games on cognitive and emotional aspects of combat-related PTSD. Paper-and-pencil questionnaires, interviews, computer-administered testing, and magnetic resonance imaging will be complete before and after the intervention. Results from this pilot study will provide information concerning feasibility and treatment potential of cognitive training for PTSD.

Conditions

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Posttraumatic Stress Disorders

Keywords

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veterans neuropsychology neuroimaging attention working memory inhibition magnetic resonance imaging, functional trauma stress anxiety emotion prefrontal cortex

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Executive function training

Executive function training

Group Type EXPERIMENTAL

Executive function training

Intervention Type BEHAVIORAL

Computer-based training in executive functions, administered via www.lumosity.com website.

Word game training

Computer-based training in tasks related to verbal processing.

Group Type PLACEBO_COMPARATOR

No interventions assigned to this group

Interventions

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Executive function training

Computer-based training in executive functions, administered via www.lumosity.com website.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* combat veterans who served in Operation Iraqi Freedom, Operation Enduring Freedom, or Operation New Dawn

Exclusion Criteria

* enrolled in other active treatment protocols
* current substance abuse or dependence
* current suicidal ideation
* diagnosis of a neurological disorder
* history of moderate to severe traumatic brain injury
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Kansas

OTHER

Sponsor Role collaborator

University of Missouri, Kansas City

OTHER

Sponsor Role lead

Responsible Party

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Robin Aupperle

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Robin Aupperle, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Missouri, Kansas City

Locations

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Univesity of Missouri - Kansas City

Kansas City, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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UMKC SS11-212e

Identifier Type: -

Identifier Source: org_study_id