COVID-19 Stroke Apical Lung Examination Study

NCT ID: NCT04640428

Last Updated: 2021-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-10

Study Completion Date

2021-10-31

Brief Summary

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Multi-centre prospective study evaluating computed tomography angiography studies performed for stroke patients as a diagnostic and prognostic imaging biomarker.

Detailed Description

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Diagnosis of coronavirus disease 2019 (COVID-19) relies on clinical features and reverse-transcriptase polymerase chain reaction (RT-PCR) testing. The latter is constrained by limited sensitivity and a timescale of hours to yield results, with no point-of-care test widely available. A dedicated computed tomography study of the chest is likely to be more sensitive than RT-PCR for COVID-19. Carotid computed tomography angiography (CTA) is a routine acute stroke investigation and includes the lung apices. We aim to assess the lung apices on CTA for ground glass opacification and compare this with COVID-19 RT-PCR test results and clinical outcome measures.

Conditions

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Covid19 Stroke, Acute Stroke, Ischemic Stroke Hemorrhagic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

All adult patients presenting with clinical features of acute ischaemic stroke undergoing investigation with computed tomography angiography at presentation.

Exclusion Criteria

Poor image quality. No radiologist report available. Computed tomography angiography performed in a non-acute setting.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute for Health Research, United Kingdom

OTHER_GOV

Sponsor Role collaborator

King's College Hospital NHS Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Royal United Hospitals Bath NHS Foundation Trust

Bath, , United Kingdom

Site Status RECRUITING

North Bristol NHS Trust

Bristol, , United Kingdom

Site Status RECRUITING

University Hospitals Bristol NHS Foundation Trust

Bristol, , United Kingdom

Site Status RECRUITING

Frimley Health NHS Foundation Trust

Camberley, , United Kingdom

Site Status RECRUITING

Cardiff and Vale University Health Board

Cardiff, , United Kingdom

Site Status RECRUITING

University Hospitals Coventry and Warwickshire NHS Trust

Coventry, , United Kingdom

Site Status RECRUITING

Leeds Teaching Hospitals NHS Trust

Leeds, , United Kingdom

Site Status RECRUITING

Guy's and St Thomas' NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

Imperial College Healthcare NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

King's College Hospital NHS FT (KCH)

London, , United Kingdom

Site Status RECRUITING

King's College Hospital NHS FT (PRUH)

London, , United Kingdom

Site Status RECRUITING

University College London NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Nathan Chan, FRCR

Role: CONTACT

+44(0)7508192126

Tom Booth, FRCR

Role: CONTACT

+44(0)2032993279

Facility Contacts

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Teo

Role: primary

Thomas Booth

Role: primary

02078489568

Other Identifiers

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COVID SALES 2

Identifier Type: -

Identifier Source: org_study_id

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