Accuracy of Transcranial Colour Coded Duplex in Comparing With CT Angiography

NCT ID: NCT06920303

Last Updated: 2025-05-13

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-05-01
• Study Completion Date: 2026-09-01

Brief Summary

Investigator will compare accuracy of transcranial colour coded duplex with CT angiography in detecting arterial obstructions in patients presenting or with history of cerebrovascular ischemic strokes

Detailed Description

Cerebrovascular stroke is one of the most common causes of death and disability in the World. It accounts for almost 5% of all disability-adjusted life-years and 10% of all deaths worldwide.

Atherosclerosis is one of the major causes of ischemic stroke, it can lead to cerebrovascular stroke through progressive stenosis, occlusion of the extra or intracranial vessels and or arterio-arterial embolization from an atheromatous plaque.

Intracranial stenosis presents with one or recurrent ischemic strokes and transient ischemic attacks.

High-grade stenosis contributes to both the occurrence and magnitude of ischemic injury.

Overall, 50% of patients have either lacunar, subcortical, or cortical infarction.

The remaining patients with intracranial stenosis have multiple lesions involving a combination of cortical, subcortical, and lacunar infarctions.

There are extensive data about carotid atherosclerosis from American, European and Asian population. However, data from Egyptian ethnics are extremely rare.

Ethnic-racial factors are related to the development of extra- and intracranial atherosclerosis.

Intracranial stenosis causes about 10% of strokes in white people, 20-29% of transient ischemic attacks or strokes in black people, and up to 40-50% of strokes in Asian people.

Extracranial atherosclerosis is common among Caucasian stroke patients. For example, in the United States and Western communities, extracranial carotid artery disease was estimated to be responsible for 20-30% of strokes, while less common in Asian and African populations.

Intracranial arterial stenosis is prevalent in the Egyptian stroke population, similar to most non-white populations.

Transcranial Doppler is routinely performed to assess the blood flow in patients with cerebral ischaemia and provides important real-time information about cerebral haemodynamics.

Transcranial doppler can aid in the diagnostic work-up by detecting, localising and grading the severity of intracranial arterial obstruction.

Transcranial Doppler is an established tool for the non-invasive assessment of cerebral blood flow. Since transcranial doppler results vary with the skills and experience of the sonographer, it requires validation against contrast angiography.

Conditions

Ischemic Stroke, Acute

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

patients who suffer from ischemic cerebrovascular stroke

All subjects must meet the following criteria to be enrolled in the study, patients who have ischemic strokes or transient ischemic attacks and will be admitted in department of neurology and psychological medicine and stroke unit at Sohag university hospital.

transcranial colour coded duplex

Intervention Type: DEVICE

transcranial colour coded duplex is good non invasive tool in detect velocity and obstructions of intracranial arteries

Interventions

transcranial colour coded duplex

transcranial colour coded duplex is good non invasive tool in detect velocity and obstructions of intracranial arteries

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• patients who have acute ischemic strokes or transient ischemic attacks .

Exclusion Criteria

1. Patients with history of cardiac arrhythmia or discovered recently or known rheumatic heart disease.

2. Patients with history of autoimmune diseases.

3. Patients with space occupying lesion or hemorrhage in Ct brain.

4. Pregnant female.

5. Patients who refuse to participate in the study.

6. Patients who have history of allergy or developed acute kidney injury during previous dye injection.

7. Patients who have chronic kidney disease.

8. Premorbid neurological disorder (myopathy, multiple sclerosis) on neurological examination or previous investigations.

9. Inability to achieve safe vascular access.

10. Patients with insufficient temporal acoustic window.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Hassan Hamdy Hamed

Resident-neurology and psychological medicine department-Sohag hospital university

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sohag university hospital

Sohag, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Hassan H Accuracy of Transcranial Colour Coded duplex Compared With CT, resident

Role: CONTACT

hassan.hamdy@med.sohag.edu.eg

+2001060583440

Hazem K Ebrahim, professor

Role: CONTACT

+2001020044243

Facility Contacts

Magdy M Amin, professor

Role: primary

References

1. DALYs GBD, Collaborators H. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1859-922. 2. Johansson BB. Hypertension mechanisms causing stroke. Clin Exp Pharmacol Physiol. 1999;26(7):563-5.. 3. Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001;32(11):2559-66.. 4. Meseguer E, Lavallee PC, Mazighi M, et al. Yield of systematic transcranial Doppler in patients with transient ischemic attack. Ann Neurol 2010;68:9-17.

Reference Type: BACKGROUND

Other Identifiers

Soh-Med--25-3-01MS

Identifier Type: -

Identifier Source: org_study_id