Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-01

Study Completion Date

2023-12-31

Brief Summary

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We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale \[mRS\] ≤ 2) and poor prognosis (mRS \> 2).

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Detailed Description

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Conditions

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The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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favorable prognosis

modified Rankin scale (mRS) ≤ 2

No interventions assigned to this group

poor prognosis

modified Rankin scale (mRS) \> 2

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Confirmed unilateral internal carotid artery/MCA atherosclerotic stenosis/occlusion with a stenosis degree \> 50% verified through computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA).
2. Presence of IS or transient ischemic attack (TIA) symptoms in the circulating blood supply area within the preceding 48 h.
3. Asymptomatic patients with no history of IS or TIA in the past 6 months.
4. Performance of 4D ASL tests during hospitalization.

Exclusion Criteria

1. Moderate-to-severe stenosis/occlusion of the contralateral internal carotid artery/middle cerebral arteries.
2. Age ≤ 18 years old.
3. Cardioembolic cerebral infarction.
4. Moyamoya disease.
5. Combined or previous cerebral hemorrhage or subarachnoid hemorrhage
6. History of previous cerebral infarction.
7. Claustrophobia or the presence of intracranial metal implants, cochlear implants, or pacemakers.

Minimum Eligible Age

18 Years

Maximum Eligible Age

88 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No