Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
949 participants
OBSERVATIONAL
2015-07-01
2017-11-30
Brief Summary
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Detailed Description
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2. New imaging technique package mainly includes conventional cranial MRI （T1,T2,T2 FLAIR,DWI, and ADC), cranial magnetic resonance angiography (MRA), and intracranial vessel wall imaging (High-Resolution Magnetic Resonance Imaging,HRMRI) as well as susceptibility weighted imaging (SWI).
3. The neurofunctional fluctuation during hospitalization as well as 90-day outcomes were carefully assessed. Patients were followed up for 90-days after stroke onset.
4. Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
2. patients with stable vital signs.
3. patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study.
Exclusion Criteria
2. patients who is extremely agitated, and cannot comply with MRI exam.
3. patients who declined the consent.
18 Years
80 Years
ALL
No
Sponsors
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Peking Union Medical College Hospital
OTHER
The Third Medical Center of Chinese PLA General Hospital
UNKNOWN
Army Medical Center of PLA
OTHER_GOV
The General Hospital of Northern Theater Command
OTHER
Subei People's Hospital of Jiangsu Province
OTHER
Second Affiliated Hospital, School of Medicine, Zhejiang University
OTHER
Beijing Jishuitan Hospital
OTHER
Fujian Medical University Union Hospital
OTHER
The First Hospital of Jilin University
OTHER
The First Affiliated Hospital of University of South China
OTHER
Qilu Hospital of Shandong University
OTHER
Tangshan Gongren Hospital
OTHER
Third Affiliated Hospital, Sun Yat-Sen University
OTHER
Renmin Hospital of Wuhan University
OTHER
China-Japan Union Hospital, Jilin University
OTHER
Shanghai Tong Ren Hospital
OTHER
Wei-Hai Xu
OTHER
Responsible Party
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Wei-Hai Xu
Associate Professor
Locations
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Beijing Jishuitan Hospital
Beijing, Beijing Municipality, China
The Third Medical Center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Army Medical Center of PLA
Chongqing, Chongqing Municipality, China
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
Third Affiliated Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, China
Tangshan Gongren Hospital
Tangshan, Hebei, China
Renmin Hospital of Wuhan University
Wuhan, Hubei, China
The First Affiliated Hospital of University of South China
Hengyang, Hunan, China
Subei People's Hospital of Jiangsu Province
Yangzhou, Jiangsu, China
The First Hospital of Jilin University
Changchun, Jilin, China
China-Japan Union Hospital of Jilin University
Changchun, Jilin, China
General Hospital of Northern Theater Command
Shenyang, Liaoning, China
Qilu Hospital of Shandong University
Qingdao, Shandong, China
Tongren Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Countries
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References
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Mazighi M, Labreuche J, Gongora-Rivera F, Duyckaerts C, Hauw JJ, Amarenco P. Autopsy prevalence of intracranial atherosclerosis in patients with fatal stroke. Stroke. 2008 Apr;39(4):1142-7. doi: 10.1161/STROKEAHA.107.496513. Epub 2008 Feb 28.
Li ML, Xu WH, Song L, Feng F, You H, Ni J, Gao S, Cui LY, Jin ZY. Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T. Atherosclerosis. 2009 Jun;204(2):447-52. doi: 10.1016/j.atherosclerosis.2008.10.019. Epub 2008 Oct 25.
Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis. Atherosclerosis. 2010 Oct;212(2):507-11. doi: 10.1016/j.atherosclerosis.2010.06.035. Epub 2010 Jun 25.
Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. Plaque distribution of stenotic middle cerebral artery and its clinical relevance. Stroke. 2011 Oct;42(10):2957-9. doi: 10.1161/STROKEAHA.111.618132. Epub 2011 Jul 28.
Xu WH, Li ML, Gao S, Ni J, Yao M, Zhou LX, Peng B, Feng F, Jin ZY, Cui LY. Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance. Ann Neurol. 2012 Feb;71(2):195-8. doi: 10.1002/ana.22626.
Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases: a high-resolution MRI Study. CNS Neurosci Ther. 2014 Apr;20(4):364-7. doi: 10.1111/cns.12224. Epub 2014 Jan 15.
Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions: a high-resolution MR imaging study. J Neurol Sci. 2014 Apr 15;339(1-2):130-3. doi: 10.1016/j.jns.2014.01.042. Epub 2014 Feb 6.
Li M, Wu SW, Xu WH. High-resolution MRI of radiation-induced intracranial vasculopathy. Neurology. 2015 Feb 10;84(6):631. doi: 10.1212/WNL.0000000000001223. No abstract available.
Zhang ZM, Si QQ, Chen HS, Yang Y, Zhang M, Wu SW, Meng Y, Li ML, Lin QQ, Liebeskind DS, Huang YN, Xu WH. High-resolution magnetic resonance imaging of acute intracranial artery thrombus. Eur J Neurol. 2023 Oct;30(10):3172-3181. doi: 10.1111/ene.15985. Epub 2023 Aug 7.
Other Identifiers
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HRMRI
Identifier Type: -
Identifier Source: org_study_id