The Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-08-31

Study Completion Date

2013-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Previous research has shown there wasn't inevitable relationship between mismatch area and infarct growth according to Volumetric-subtraction mismatch volume.The recently published on Stroke paper has proposed Coregistration mismatch to calculate the mismatch to replace ischaemic penumbra, and it reignites hope for clinical application of the PWI/DWI mismatch. But the correlation between the mismatch, calculated by Coregistration mismatch method,and the clinical outcome of the patients with acute ischemic stroke is still unknown. so the investigators plan to conduct a prospective observational cohort study.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging

NCT06289036

The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke

COMPLETED

A Longitudinal Study of Multimodal Resonance Imaging in Stroke Patients

NCT02024503

Stroke

UNKNOWN

Brain MRI in Stroke Patients With Intracardiac Thrombus

NCT04456309

Stroke Intracardiac Thrombus

COMPLETED

MRI-SWI as a Predictor of Functional Outcome in Acute Ischemic Stroke

NCT00696306

Acute Ischemic Stroke Stroke Cerebral Stroke +1 more

COMPLETED

Medical Imaging Screening for Posterior-circulation Ischemic Stroke

NCT06094569

Endovascular Thrombectomy

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

NIHSS,mRS and MR PWI/DWI/MRA are performed within 48 hours of stroke onset and final MR T2/flair image at ≈1 month. And then,Volumetric-subtraction mismatch and Coregistered mismatch will be calculated,respectively.finally,we will assess and compare the Volumetric-subtraction mismatch and Coregistered mismatch, and to clarify which method match the clinical outcome more better.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ischemic Stroke

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Aged eighteen or above
* Acute middle cerebral artery ischemic stroke
* Stroke onset within 48 hours
* Included a complete set of initial MR images and final outcome MR images up to 1 months

Exclusion Criteria

* History of stroke in the past 6 weeks
* Pre-existing neurological or psychiatric disease that could confound the study results such as a pre-stroke mRS score greater than 3
* CT evidence of the following conditions before enrollment:

Significant mass effect with midline shift Evidence of intracranial hemorrhage

* With contraindication to MR such as severe allergy to contrast media

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No