MRI Biomarkers of Effective Tissue Reperfusion After Thrombectomy of an Acute Proximal Occlusion of the Anterior Circulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-15

Study Completion Date

2024-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Cerebral infarction by proximal occlusion of the anterior circulation is common with major personal and societal consequences.

MRI is the gold standard for exploring stroke, especially ischemic, and a number of biomarkers on initial MRI (before reperfusion) are predictive of neurological prognosis. However, their spatiotemporal evolution in the suites of reperfusion is unclear.

Close monitoring by MRI would make it possible to precisely know the tissue, vascular and microvascular evolution of the infarct area and the penumbra after reperfusion, and thus to characterize MRI biomarkers associated with efficient tissue reperfusion.

The aim of the MR-Reperfusion study is to characterize new MRI biomarkers of efficient tissue reperfusion.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Brain MRI in Stroke Patients With Intracardiac Thrombus

NCT04456309

Stroke Intracardiac Thrombus

COMPLETED

Assessment of One-shot Cardiac-cervical-intracranial MRI in the Etiological Work up of Ischemic Stroke and Transient Ischemic Attacks

NCT04790357

Ischemic Stroke Transient Ischemic Attack

UNKNOWN NA

Reperfusion Therapy in Acute Ischemic Stroke With Unclear Onset

NCT01138059

Stroke

COMPLETED

Stroke Imaging Package Study

NCT02485275

Acute Ischemic Stroke Intracranial Arteriosclerosis Cerebral Small Vessel Diseases

COMPLETED

Intracerebral Hemorrhage Due to Oral Anticoagulants: Prediction of the Risk by Magnetic Resonance

NCT02238470

Ischemic Stroke

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ischemic Stroke, Acute

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Experimental

Group Type EXPERIMENTAL

MRI

Intervention Type DEVICE

Magnetic Resonance Imaging (MRI)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

MRI

Magnetic Resonance Imaging (MRI)

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* To be over 18 year-old
* Perfusion MRI assessment on admission;
* Admission for an acute infarction of the anterior circulation with proximal occlusion (tandem, distal internal carotid, or M1 segment of the middle cerebral artery);
* Initial mTICI = 0-1 on the initial angiography before treatment;
* Patient in complete autonomy (mRS ≤ 2) before the onset of symptoms;
* Mechanical thrombectomy (in combination or not with intravenous thrombolysis), within the first 6 hours of the onset of symptoms, or within 24 hours in case of clinical-radiological or radiological mismatch;
* Success of reperfusion estimated by an mTICI = 3 at the end of the procedure;
* Availability of MRI within 3 hours of angiographic reperfusion;
* To be able to understand the instructions given;
* Written consent given by the patient or a trusted person;
* To be enrolled in a social security plan;