Multimodal Investigation of Intracranial Clot Environment

NCT ID: NCT04421326

Last Updated: 2024-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-14

Study Completion Date

2025-10-31

Brief Summary

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Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage

Detailed Description

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It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.

Conditions

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Acute Ichemic Stroke Brain Ischemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with acute ischemic stroke

Patients undergoing Mechanical Thrombectomy for large vessel occclusion with acute ischemic stroke

Analysis of the clot

Intervention Type OTHER

Blood sampling at the site of intracranial occlusion during Mechanical Thrombectomy

Interventions

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Analysis of the clot

Blood sampling at the site of intracranial occlusion during Mechanical Thrombectomy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Over 18 years of age,
2. Non-dependent for activities of daily living prior to the onset of the MI (Modified Rankin Score \>2)
3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI or angio-scanner).

Exclusion Criteria

1. Patients initially admitted but for whom endovascular treatment will not finally be performed (re-infusion, catheterization failure...) will be excluded from the study.
2. Major patients under guardianship or curatorship or patients deprived of liberty
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Genomic Institute of Montpellier

UNKNOWN

Sponsor Role collaborator

University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vincent COSTALAT, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Montpellier University Hospital

Locations

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University Hospital of Montpellier

Montpellier, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Cyril DARGAZANLI, MD MSc

Role: CONTACT

467337532 ext. +33

Vincent COSTALAT, MD PhD

Role: CONTACT

467337532 ext. +33

Facility Contacts

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Vincent COSTALAT

Role: primary

0467337274

Other Identifiers

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RECHMPL18_0236

Identifier Type: -

Identifier Source: org_study_id

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