Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-07

Study Completion Date

2021-06-12

Brief Summary

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Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.

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Detailed Description

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Conditions

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Stroke Systemic Infection

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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AVC

Patients hospitalized for TM after a proximal ischemic stroke of the middle cerebral artery and whose reperfusion is satisfactory (TICI 2b, 2c and 3). Additional blood sample will be taken during usual treatment the day of the stroke.

Blood sample

Intervention Type BIOLOGICAL

Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke

Control

Population of control patients, consisting of patients admitted on an outpatient basis for a diagnostic cerebral arteriography.

Blood sample

Intervention Type BIOLOGICAL

Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke

Interventions

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Blood sample

Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Adults patient (s)
* Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1)
* Initial diagnostic MRI infusion
* TM with complete reperfusion (TICI 2b, 2c or 3)
* TM performed under local anesthesia +/- anxiolysis, or sedation including propofol
* mRS prior to stroke \<2
* Barthel index \<90
* Included in the HIBISCUS cohort
* Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible

* Adults patient (s)
* mRS \<2
* Barthel index \<90
* Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation
* Patient who was informed and did not object to participating in the study

Exclusion Criteria

* NIHSS awareness score\> or = 2
* Haemorrhagic complication before thrombectomy
* Pregnant woman
* Multiple vascular occlusions
* Occlusions of posterior or anterior cerebral territories other than M1
* Protected major
* TM performed under general anesthesia
* Other vital failure than neurological failure

GROUP "CONTROL" :

* NIHSS awareness score\> or = 2
* Pregnant woman
* Protected major
* Exam performed under general anesthesia

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No