Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia
NCT ID: NCT07033988
Last Updated: 2025-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
380 participants
OBSERVATIONAL
2025-06-30
2030-05-31
Brief Summary
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The overarching aim of this study is to advance the understanding of the pathogenesis of cerebral ischemia and to support the development of novel therapeutic strategies for cerebrovascular disease. Specifically, the research seeks to elucidate the pathophysiological mechanisms involved in thrombus formation and stabilization that lead to ischemic events, identify thrombus compositions associated with distinct stroke etiologies, and determine features predictive of resistance to current intravenous thrombolytic therapies. In addition, the study aims to discover novel therapeutic targets and to identify circulating blood biomarkers indicative of an elevated risk of thrombosis.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Stroke_Patients
This cohort includes adult patients diagnosed with acute ischemic stroke due to large vessel occlusion (LVO); subgroups within the cohort may include patients with different etiologies based on standard diagnostic classifications and stratification may be performed by response to thrombolysis, histological thrombus composition, or systemic biomarkers.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Presentation to the emergency department with symptoms and/or signs suggestive of:
* An acute cerebrovascular event
* Stroke mimics
* Stroke-related risk factors (e.g., atrial fibrillation, endocarditis, significant internal carotid stenosis, neoplasms, systemic infections)
* Undergoing one of the following treatments:
* Mechanical thrombectomy
* Intravenous thrombolysis
* Standard medical therapy
* Provision of informed consent, either:
* Directly from the conscious patient
* Via appropriate procedures for unconscious patients
Exclusion Criteria
* Presence of a known autoimmune disease that could interfere with the interpretation of biomarker analyses
18 Years
ALL
No
Sponsors
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IRCCS San Raffaele
OTHER
University of Zurich
OTHER
University of Manchester
OTHER
German Cancer Research Center
OTHER
Responsible Party
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Bacigaluppi Marco
Principal Investigator
Locations
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Neurology
Milan, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CET 96-2025
Identifier Type: -
Identifier Source: org_study_id
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