Influence of Circulating Endothelial Progenitor Cells and Modifiable Vascular Risk Factors on Carotid Plaque Vulnerability

NCT ID: NCT03218527

Last Updated: 2017-07-14

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 120 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-10-01
• Study Completion Date: 2018-12-31

Brief Summary

Ischemic stroke is a leading cause of death and disability worldwide. Atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation, cell proliferation and ultimately to vessel stenosis. One of the main features related to plaque progression and vulnerability is inflammation. Positron emission tomography with 18-fluorodeoxyglucos (18-FDG PET) allows an accurate quantification of plaque inflammation and it has been proved its usefulness in predicting early stroke recurrences. The investigators aim to test how modifiable vascular risk factors influence plaque inflammation assessed by 18-FDG PET. In addition, investigators will assess the association of this inflammation and circulating endothelial progenitor cells

Conditions

Atherosclerosis; Stroke; Inflammation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Ischemic stroke within 7 days before inclusion
• At least one atherosclerotic plaque in the internal carotid artery
• >18 years old

Exclusion Criteria

• Cardioembolic strokes according to TOAST criteria
• Poor functional outcome (Rankin >3) after stroke

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Instituto de Salud Carlos III

OTHER_GOV

Sponsor Role: collaborator

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hospital de la Santa Creu i Sant Pau

Barcelona, , Spain

Site Status: RECRUITING

Countries

Spain

Central Contacts

Pol Camps-Remom, MD

Role: CONTACT

pcamps@santpau.cat

+34660030907

Facility Contacts

Pol Camps-Renom, MD

Role: primary

pcamps@santpau.cat

+34660030907

References

Garcia E, Camps-Renom P, Puig N, Fernandez-Leon A, Aguilera-Simon A, Benitez-Amaro A, Sole A, Vilades D, Sanchez-Quesada JL, Marti-Fabregas J, Jimenez-Xarrie E, Benitez S, Llorente-Cortes V. Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke. J Transl Med. 2023 Feb 19;21(1):131. doi: 10.1186/s12967-022-03867-w.

Reference Type: DERIVED

PMID: 36805772 (View on PubMed)

Other Identifiers

IIBSP-ATE-2015-38

Identifier Type: -

Identifier Source: org_study_id