Endothelial Function and Progenitor Cells in Acute Ischemic Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-07-31

Study Completion Date

2012-06-30

Brief Summary

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The purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cEPC) are increased in the acute phase of ischemic stroke.

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Detailed Description

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Endothelial dysfunction is a key component of atherosclerosis which contributes to the development of cardio- and cerebrovascular diseases. However, endothelial dysfunction (ED) is not established as a risk factor for ischemic stroke.

As a novelty the proposed trial investigates the following variety of indirect markers of endothelial function in acute ischemic stroke:

circulating endothelial progenitor cells (EPC), endothelial microparticles (EMP), ENDOPAT (RH- PAT ratio) in two regards:

1. time after ischemic events (\< 48h, Days 4-5, day 7 or at discharge)
2. etiological stroke subtypes

It is not known whether these parameters are changed after acute cerebral ischemia and could possibly serve as specific target for treatment.

Conditions

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Ischemic Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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first-ever ischemic stroke

first-ever ischemic stroke according to the WHO definition

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with first ever ischemic stroke
* TIA, or transient symptoms with infarction (TSI)
* Age \> or = 18 years old within 24 hours after onset
* Written informed consent to participate
* No evidence for dysphagia

Exclusion Criteria

* Malignant hematopoietic disease (e.g. leukemia), severe systemic infections, severe immunological disease, renal or hepatic failure
* Pancreatitis, cholecystolithiasis, intestinal malabsorption
* Lactose intolerance
* Increased risk of aspiration
* Pregnancy
* Life expectancy less than 12 months
* Inability to give written informed consent
* Psychosis
* Alcohol dependency
* Abuse of illegal drugs

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No