Timed Interval Measurement of Eotaxin in Stroke Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-22

Study Completion Date

2019-05-30

Brief Summary

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Stroke is caused by sudden changes in blood flow in the brain. This can be fatal or can result in permanent disability. A fast diagnosis is essential to initiate effective interventions and optimize benefits to patients. There are other diseases that can look like a stroke and these are called "stroke mimics". The quicker that stroke mimics can be ruled out the faster a stroke can be diagnosed and treatment can be given. The investigators may be able to use chemicals in the blood to rapidly confirm that a person has had a stroke. One such chemical is called eotaxin. Eotaxin has been found to be changed in sufferers of a stroke but not in those with stroke mimics. However, more research is needed to confirm the usefulness of eotaxin. This feasibility study aims to provide the foundations to allow a large scale trial of this test. The study aims to recruit participants that have had a stroke or a stroke mimic from the Acute Stroke Unit and Stroke clinic at the Royal Devon and Exeter Hospital. Up to 6 blood samples will be taken from each participant at different times over one week. Eotaxin will be measured in these samples and in participant's leftover samples taken for clinical care. This is needed because the investigators know that the amount of eotaxin changes in the blood after a stroke but we do not know how quickly this change happens and for how long the change occurs. The study will also allow the investigators to understand how many participants will be needed for a large scale trial and the challenges that may be faced in recruiting participants.

Detailed Description

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Conditions

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Stroke, Acute

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Stroke Symptom Participants

No interventions assigned to this group

Healthy Controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Presenting with focal neurological symptoms suggestive of stroke
* Aged over 18 years

Exclusion Criteria

* Presenting later than 12 hours after symptom onset
* Under 18 years of age
* History of cardiovascular disease (Healthy Controls)
* History of neurological disease (Healthy Controls)
* History of stroke mimics (Healthy Controls)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Salim Elyas, PhD MRCP

Role: PRINCIPAL_INVESTIGATOR

Royal Devon and Exeter NHS Foundation Trust

Locations

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Royal Devon & Exeter NHS Foundation Trust

Exeter, Devon, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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Protocol v5 15/05/17

Identifier Type: -

Identifier Source: org_study_id