Acute Effect of Passive Joint Mobilization in Non-Specific Neck Pain

NCT ID: NCT04605510

Last Updated: 2022-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-01

Study Completion Date

2022-05-23

Brief Summary

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Aim of present study is investigating the acute effects of passive joint mobilization on pain perception and range of motion. Study protocol includes passive joint mobilization application to study group with neck pain and blood sample collection of study and healthy control group.

Detailed Description

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Our purpose of planning this study is to examine the acute effect of passive joint mobilization application on pain perception and range of motion in women with non-specific neck pain.

The hypotheses we will test for this purpose;

H1- Passive joint mobilization application increases the range of motion of the cervical joint in women with non-specific neck pain.

H2- Passive joint mobilization application increases the pressure pain threshold in women with non-specific neck pain.

H3- Passive joint mobilization increases serum Orexin A and Neurotensin levels in women with non-specific neck pain.

Conditions

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Neck Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

This study includes two groups. Intervention group including women with non-specific neck pain will applied cervical passive joint mobilization and assessment protocol. Control group including healthy women without pain will applied only assessment protocol.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intervention Group

24 female participants with non-specific neck pain included in the mobilization group will undergo detailed manual cervical examination. In the evaluation, the most painful segment with dysfunction will be selected and mobilization application and algometric measurements will be performed on this segment. Grade 3 Central Posterior-Anterior (CPA) passive joint mobilization with Maitland method will be applied in 3 sets, 30 seconds, to the segment with the detected dysfunction.

Group Type EXPERIMENTAL

Passive Cervical Joint Mobilization

Intervention Type OTHER

It will be applied to the cervical spine, whose dysfunction is detected as a result of the evaluation. The participant will be in the prone position and Grade 3 Central Posterior-Anterior (CPA) passive joint mobilization with Maitland method will be applied for 3 sets, 30 seconds, to the segment to be treated.

Healthy Control Group

Healthy volunteer participants included in the control group will only be applied an evaluation protocol and blood samples will be taken without any application.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Passive Cervical Joint Mobilization

It will be applied to the cervical spine, whose dysfunction is detected as a result of the evaluation. The participant will be in the prone position and Grade 3 Central Posterior-Anterior (CPA) passive joint mobilization with Maitland method will be applied for 3 sets, 30 seconds, to the segment to be treated.

Intervention Type OTHER

Other Intervention Names

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Maitland Mobilization

Eligibility Criteria

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Inclusion Criteria

For Intervention Group;

* Having neck pain lasting more than 30 days and being diagnosed with non-specific neck pain
* Having obtained 14/50 points and above in Neck Disability Index
* Expressing neck pain at least 34/100 points and above on a Visual Analog Scale
* Being 20-45 years old and female

For Healthy Control Group;

\- Healthy volunteers without a chronic illness and musculoskeletal pain

Exclusion Criteria

* Congenital anomalies
* Previously diagnosed orthopedic diseases related to the spine
* Pregnancy and having just given birth
* Within the last 3 months; use of corticosteroids, cytotoxic drugs, or immunosuppressants
* Liver or kidney failure
* Acute or chronic infections (including HIV)
* Serious pathologies (such as cancer, spondylolisthesis, rheumatoid arthritis or ankylosing spondylitis)
* Symptoms of cervical spinal stenosis (such as incoordination of hands, arms and legs, bowel and bladder incontinence)
* Radix compression (such as sensory changes, muscle weakness or decreased reflexes)
* Whiplash or a history of cervical surgery
Minimum Eligible Age

24 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Pamukkale University

OTHER

Sponsor Role collaborator

Mücahit ÖZTOP

OTHER

Sponsor Role lead

Responsible Party

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Mücahit ÖZTOP

Research Assistant

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Nesrin YAĞCI, Professor

Role: STUDY_DIRECTOR

Pamukkale University School of Physical Therapy and Rehabilitation

Locations

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Pamukkale University School of Physical Therapy and Rehabilitation

Denizli, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Plaza-Manzano G, Molina-Ortega F, Lomas-Vega R, Martinez-Amat A, Achalandabaso A, Hita-Contreras F. Changes in biochemical markers of pain perception and stress response after spinal manipulation. J Orthop Sports Phys Ther. 2014 Apr;44(4):231-9. doi: 10.2519/jospt.2014.4996. Epub 2014 Jan 22.

Reference Type BACKGROUND
PMID: 24450367 (View on PubMed)

Molina-Ortega F, Lomas-Vega R, Hita-Contreras F, Plaza Manzano G, Achalandabaso A, Ramos-Morcillo AJ, Martinez-Amat A. Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception. Man Ther. 2014 Oct;19(5):411-7. doi: 10.1016/j.math.2014.02.007. Epub 2014 Mar 5.

Reference Type BACKGROUND
PMID: 24674816 (View on PubMed)

Lohman EB, Pacheco GR, Gharibvand L, Daher N, Devore K, Bains G, AlAmeri M, Berk LS. The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trial. J Man Manip Ther. 2019 Sep;27(4):186-196. doi: 10.1080/10669817.2018.1553696. Epub 2018 Dec 11.

Reference Type BACKGROUND
PMID: 30935335 (View on PubMed)

Maitland GD. Maitland's Vertebral Manipulation. Seventh Ed. (Hengeveld E, Banks K, eds.). Edinburgh; New York: Churchill Livingstone; 2013. https://www.elsevier.com/books/maitlands-vertebral-manipulation/hengeveld/978-0-7020-4066-5.

Reference Type BACKGROUND

Other Identifiers

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60116787-020/46072

Identifier Type: -

Identifier Source: org_study_id

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