A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis

NCT ID: NCT04594707

Last Updated: 2024-05-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

117 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-30

Study Completion Date

2023-02-10

Brief Summary

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This study will evaulate the long-term safety, efficacy and pharmacokinetics (PK) of recombinant human pentraxin-2 (rhPTX-2; PRM-151) zinpentraxin alfa, administered by intravenous (IV) infusion to participants with idiopathic pulmonary fibrosis (IPF).

Detailed Description

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This study is being conducted for the treatment of eligible participants who have taken part in Study PRM-151-202 and received the open-label study drug or completed the Phase III Study WA42293 with PRM-151. Participants who have discontinued treatment from or have completed Study WA42293 and do not want to receive PRM-151 in this study, will be invited to enroll in survival follow-up.

Conditions

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Idiopathic Pulmonary Fibrosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Zinpentraxin Alfa

Corhort A: Participants entering, following participation in study PRM-151-202.

Cohort B: Participants entering, following participation in study WA42293.

Group Type EXPERIMENTAL

PRM-151 (Zinpentraxin Alfa)

Intervention Type DRUG

Cohort A: Participants will receive three loading doses of open-label PRM-151 on days 1, 3, and 5, then one infusion every 4 weeks (Q4W). 10 mg/kg of PRM 151 will be administered by intravenous (IV) infusion over 60 minutes on days 1, 3, and 5, then one infusion every 4 weeks.

Cohort B: Participants previously randomized to the placebo in WA42293 will receive study medication in the three loading doses on days 1, 3 and 5 in a blinded fashion. All three doses will contain PRM-151. Participants previously randomized to the treatment arm in WA42293 will receive study medication in the three loading doses on days 1, 3 and 5 in a blinded fashion. One of the three doses will contain PRM-151, whereas two doses will contain placebo.

Interventions

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PRM-151 (Zinpentraxin Alfa)

Cohort A: Participants will receive three loading doses of open-label PRM-151 on days 1, 3, and 5, then one infusion every 4 weeks (Q4W). 10 mg/kg of PRM 151 will be administered by intravenous (IV) infusion over 60 minutes on days 1, 3, and 5, then one infusion every 4 weeks.

Cohort B: Participants previously randomized to the placebo in WA42293 will receive study medication in the three loading doses on days 1, 3 and 5 in a blinded fashion. All three doses will contain PRM-151. Participants previously randomized to the treatment arm in WA42293 will receive study medication in the three loading doses on days 1, 3 and 5 in a blinded fashion. One of the three doses will contain PRM-151, whereas two doses will contain placebo.

Intervention Type DRUG

Other Intervention Names

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Zinpentraxin Alfa

Eligibility Criteria

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Inclusion Criteria

* Taken part in either of the prior PRM-151 studies: PRM-151-202 or WA42293.
* For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception.
* For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.

Exclusion Criteria

* Acute respiratory or systemic bacterial, viral, or fungal infection at the first visit of the OLE, or within 2 weeks of the first visit for patients joining Cohort A (from Study PRM-151-202).
* History of smoking within 3 months prior to the first visit in the OLE.
* History of alcohol or substance use disorder within 2 years prior to the first visit of the OLE or known or suspected active alcohol or substance-use disorder.
* History of severe allergic reaction or anaphylactic reaction to PRM-151.
* Clinically significant abnormality on ECG during eligibility assessment that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant.
* Prolonged corrected QT interval \> 450 ms (for men) or \> 470 ms (for women) based on the Fridericia correction formula.
* Clinically significant laboratory test abnormalities (hematology, serumchemistry, and urinalysis) that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

University of California Davis

Sacramento, California, United States

Site Status

Inst. of Healthcare Assessment, Inc.

San Diego, California, United States

Site Status

UCSF Medical Center

San Francisco, California, United States

Site Status

National Jewish Health Medical Center

Denver, Colorado, United States

Site Status

Yale New Haven Hospital

New Haven, Connecticut, United States

Site Status

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

Site Status

Meris Clinical Research

Brandon, Florida, United States

Site Status

Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration

Celebration, Florida, United States

Site Status

Advanced Pulmonary & Sleep Research Institute of Florida

Daytona Beach, Florida, United States

Site Status

University of Florida Health Pulmonology - Jacksonville

Jacksonville, Florida, United States

Site Status

Advanced Pulmonary Research Institute

Loxahatchee Groves, Florida, United States

Site Status

Sarasota County Public Hospital

Sarasota, Florida, United States

Site Status

Renstar Medical Research

Wesley Chapel, Florida, United States

Site Status

Florida Pulmonary Research Institute, LLC

Winter Park, Florida, United States

Site Status

NorthShore University HealthSystem

Evanston, Illinois, United States

Site Status

University of Iowa Hospitals and Clinics; Investigational Drug Services

Iowa City, Iowa, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

University of Louisville Health Sciences Center

Louisville, Kentucky, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

University of Minnesota Medical Center

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

The Lung Research Center

Chesterfield, Missouri, United States

Site Status

Washington University

St Louis, Missouri, United States

Site Status

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status

Lenox Hill Hospital

New York, New York, United States

Site Status

Pulmonix Research

Greensboro, North Carolina, United States

Site Status

PMG Research of Wilmington

Wilmington, North Carolina, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

Jefferson University Physicians (JUP) - Jefferson Pulmonary

Philadelphia, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

SleepMed of South Carolina

Columbia, South Carolina, United States

Site Status

Lowcountry Lung and Critical Care

North Charleston, South Carolina, United States

Site Status

Spartanburg Medical Center

Spartanburg, South Carolina, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

University of Texas Medical Branch at Galveston

Galveston, Texas, United States

Site Status

Metroplex Pulmonology & Sleep Center

McKinney, Texas, United States

Site Status

University Of Utah Hosp & Clin; Investigational Pharmacy

Salt Lake City, Utah, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Virginia Commonwealth University

Richmond, Virginia, United States

Site Status

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, , Argentina

Site Status

Fundacion Respirar (Centro Medico Dra. De Salvo)

Ciudad Autonoma Buenos Aires, , Argentina

Site Status

Instituto de Medicina Respiratoria, IMeR; Clinic/Outpatient Facility

Córdoba, , Argentina

Site Status

Hospital Universitario Austral

Derqui-Pilar, , Argentina

Site Status

Centro Medico de Enfermedades Respiratorias (CEMER)

Florida, Buenos Aires, , Argentina

Site Status

Centro de estudios respiratorios

Mar del Plata, , Argentina

Site Status

Fundacion Scherbovsky

Mendoza, , Argentina

Site Status

INSARES

Mendoza, Mendoza City, , Argentina

Site Status

Instituto Medico de la Fundacion Estudios Clinicos

Rosario, , Argentina

Site Status

Investigaciones en Patologias Respiratorias

San Miguel de Tucumán, , Argentina

Site Status

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Cairns Base Hospital; Cancer Care Centre

Cairns, Queensland, Australia

Site Status

Lung Research Queensland

Nundah, Queensland, Australia

Site Status

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Site Status

Monash Medical Centre; Medicine

Melbourne, Victoria, Australia

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The Alfred Hospital

Prahan, Victoria, Australia

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ULB Hôpital Erasme

Brussels, , Belgium

Site Status

Cliniques Universitaires Saint-Luc; Pharmacy

Brussels, , Belgium

Site Status

UZ Leuven

Leuven, , Belgium

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C. H. U. Sart-Tilman; Laboratory

Liège, , Belgium

Site Status

CHU UCL Namur / site Godinne

Yvoir, , Belgium

Site Status

Synergy Respiratory Care

Sherwood Park, Alberta, Canada

Site Status

Kelowna Respiratory and Allergy Clinic

Kelowna, British Columbia, Canada

Site Status

The Rhema Research Institute

Owen Sound, Ontario, Canada

Site Status

Dr. Syed Anees Medicine Profession Corporation

Windsor, Ontario, Canada

Site Status

C.I.C. Mauricie

Trois-Rivières, Quebec, Canada

Site Status

Beijing Friendship Hospital Affiliated of Capital University of Medical Science

Beijing, , China

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Peking Union Medical College Hospital; Pharmacy

Beijing, , China

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The Second Xiangya Hospital of Central South University

Changsha, , China

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The Third Xiangya Hospital Of Central South University

Changsha, , China

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Shengjing Hospital of China Medical University

Shenyang, , China

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Hebei Medical University - The Second Hospital

Shijiazhuang, , China

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Tianjin Medical University General Hospital

Tianjin, , China

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Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, , China

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Wuxi People's Hospital

Wuxi, , China

Site Status

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, , China

Site Status

Fakultni nemocnice Brno

Brno, , Czechia

Site Status

Fakultni Nemocnice; Interni Klinika - odd. Invazivni Kardiologie

Hradec Králové, , Czechia

Site Status

Thomayerova nemocnice; Lekarna - pavilon H

Prague, , Czechia

Site Status

Krajska nemocnice T. Bati a.s.; Neurologicke oddeleni

Zlín, , Czechia

Site Status

Gentofte Hospital

Hellerup, , Denmark

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Odense Universitetshospital

Odense C, , Denmark

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Hopital Avicenne

Bobigny, , France

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Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche

Brest, , France

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Hopital Louis Pradel

Bron, , France

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CHU Hopitaux de Bordeaux

CHU Hopitaux de Bordeaux, , France

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CHU Dijon Bourgogne Hôpital François Mitterand

Dijon, , France

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CHU de Grenoble - Hôpital André Michallon; Pole Pharmacie

La Tronche, , France

Site Status

Centre Hospitalier Regional Universitaire de Lille

Lille, , France

Site Status

Servie de Pneumologie et centre de Transplantation Pulmonaire

Marseille, , France

Site Status

CHU Nice - Hôpital Pasteur 2

Nice, , France

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Hopital Bichat Claude Bernard; Hepatologie Gastro Enterologie

Paris, , France

Site Status

Centre Hospitalier Universitaire de Reims; l'Hopital Maison Blanche

Reims, , France

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Centre Hospitalier Universitaire de Rennes

Rennes, , France

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CHU Tours - Hôpital Bretonneau

Tours, , France

Site Status

Evang. Lungenklinik Berlin Klinik für Pneumologie

Berlin, , Germany

Site Status

Thoraxklinik-Heidelberg gGmbH; Apotheke der Thoraxklinik

Heidelberg, , Germany

Site Status

Lungenfachklinik Immenhausen

Immenhausen, , Germany

Site Status

Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup

Marburg, , Germany

Site Status

Lungenklinik Münnerstadt, Thoraxzentrum Bezirk Unterfranken

Münnerstadt, , Germany

Site Status

Krankenhaus Bethanien gGmbH

Solingen, , Germany

Site Status

Evangelismos Hospital; Endocrinology, Diabetes & Metabolism

Athens, , Greece

Site Status

Attikon University General Hospital

Chaïdári, , Greece

Site Status

University General Hospital of Heraklion

Heraklio, , Greece

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University Hospital of Ioannina; Pulmonology Department

Ioannina, , Greece

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Athens Medical Center

Marousi, , Greece

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University of Thessaly Faculty of Medicine

Mezourlo, , Greece

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University General Hospital of Patras

Pátrai, , Greece

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"General hospital of Chest Diseases ""Sotiria"", 7th Pulmonary Clinic "

Sotiria Athens, , Greece

Site Status

General Hospital of Thessaloniki G. Papanikolaou

Thessaloniki, , Greece

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Prince of Wales Hospital; Dept. of Medicine & Therapeutics

Hong Kong, , Hong Kong

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The University of Hong Kong; Queen Mary Hospital

Hong Kong, , Hong Kong

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Semmelweis University

Budapest, , Hungary

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Debreceni Egyetem

Debrecen, , Hungary

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Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET

Szombathely, , Hungary

Site Status

Szent Borbala Korhaz

Tatabánya, , Hungary

Site Status

Tudogyogyintezet Torokbalint; Onkologiai és Jarobeteg Centrum

Törökbálint, , Hungary

Site Status

Barzilai Medical Center; Neurology Department

Ashkelon, , Israel

Site Status

Ben-Gurion University of the Negev - Soroka University Medical Center - Pulmonology Institute

Beersheba, , Israel

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Shamir medical center

Be’er Ya‘aqov, , Israel

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Rambam Health Care Campus

Haifa, , Israel

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Edith Wolfson Medical Center

Holon, , Israel

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Shaare Zedek Medical Center

Jerusalem, , Israel

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Hadassah Medical Center

Jerusalem, , Israel

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Meir Medical Center

Kfar Saba, , Israel

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Rabin Medical Center

Petach Tiqwa, , Israel

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The Chaim Sheba Medical Center

Ramat Gan, , Israel

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Kaplan Medical Center

Rehovot, , Israel

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Tel Aviv Sourasky Medical Center; Department of Neurology

Tel Aviv, , Israel

Site Status

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, Abruzzo, Italy

Site Status

Policlinico Riuniti di Foggia - Department of Medical and Surgical Sciences - University of Foggia

Foggia, Apulia, Italy

Site Status

"AZIENDA OSPEDALIERA DEI COLLI Monaldi-Cotugno-CTO - Pneumologia "

Napoli, Campania, Italy

Site Status

Azienda Ospedaliera Universitaria Federico II

Napoli, Campania, Italy

Site Status

Ospedale Morgagni Pierantoni; Patologia clinica

Forlì, Emilia-Romagna, Italy

Site Status

A.O.U. Policlinico di Modena

Modena, Emilia-Romagna, Italy

Site Status

Policlinico Tor Vergata - U.O.C. Malattie Apparato Respiratorio

Rome, Lazio, Italy

Site Status

Fondazione Policlinico Universitario A Gemelli; Servizio di Farmacia

Rome, Lazio, Italy

Site Status

Ospedale San Giuseppe; U.O. di Pneumologia

Milan, Lombardy, Italy

Site Status

Asst Santi Paolo E Carlo

Milan, Lombardy, Italy

Site Status

Ospedale San Gerardo

Monza, Lombardy, Italy

Site Status

Fondazione IRCCS Policlinico San Matteo Divisione di EmatologiaDipartimento di Onco-Ematologia

Pavia, Lombardy, Italy

Site Status

A.O.U. Sassari; Dip. Medicina Clinica e Sperimentale

Sassari, Sardinia, Italy

Site Status

Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele

Catania, Sicily, Italy

Site Status

Az. Osp. Univ. P. Giaccone; UOC di Pneumologia

Palermo, Sicily, Italy

Site Status

Ismett Istituto Mediterraneo Trapianti E Terapie Alta Specializzazione;Pneumologia

Palermo, Sicily, Italy

Site Status

AOUC Azienda Ospedaliero-Universitaria Careggi; Neurologia 2

Florence, Tuscany, Italy

Site Status

A.O. Univ. Senese Policlinico S. Maria alle Scotte; Dip. Medicina clinica e Scienze Immunologiche

Siena, Tuscany, Italy

Site Status

Azienda Ospedale Universita Di Padova; Divisione Clinicizzata Di Nefrologia 1

Padua, Veneto, Italy

Site Status

University of Padova Ca' Foncello Hospital Immunologic & Respiratory Rare Diseases Center

Treviso, Veneto, Italy

Site Status

Nagoya University Hospital

Aichi, , Japan

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Chiba University Hospital

Chiba, , Japan

Site Status

National Hospital Organization Kyushu Medical Center

Fukuoka, , Japan

Site Status

Fukuoka University Hospital

Fukuoka, , Japan

Site Status

Kobe City Medical Center General Hospital

Hyōgo, , Japan

Site Status

National Hospital Organization Himeji Medical Center

Hyōgo, , Japan

Site Status

Kameda Medical Center

Kamogawa, , Japan

Site Status

Kanagawa Cardiovascular and Respiratory Center

Kanagawa, , Japan

Site Status

Nippon Medical School Musashi Kosugi Hospital

Kawasaki-Shi, , Japan

Site Status

Saiseikai Kumamoto Hospital

Kumamoto, , Japan

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Nagasaki University Hospital

Nagasaki, , Japan

Site Status

National Hospital Organization Ibarakihigashi National Hospital; Center for Clinical Research

Naka-gun, , Japan

Site Status

Kurashiki Central Hospital

Okayama, , Japan

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National Hospital Organization Kinki-Chuo Chest Medical Center

Sakaishi, , Japan

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Tosei General Hospital

Seto-shi, , Japan

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Tenri Hospital

Tenri-Shi, , Japan

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Jichi Medical University Hospital

Tochigi, , Japan

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Tokushima University Hospital

Tokushima, , Japan

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Tokyo Medical Ando Dentaluni Hospital Faculty of Medicine; Surgical Oncology

Tokyo, , Japan

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Center Hospital of the National Center for Global Health and Medicine

Tokyo, , Japan

Site Status

INER- Instituto Nacional de Enfermedades Respiratorias"Ismae

Mexico City, Mexico CITY (federal District), Mexico

Site Status

Centro Respiratorio de México

México, Mexico CITY (federal District), Mexico

Site Status

Unidad Médica para la Salud Integral UMSI

San Nicolás de los Garza, Nuevo León, Mexico

Site Status

Unidad de Investigacion CIMA SC

Chihuahua City, , Mexico

Site Status

CICC Morelia

Morelia, , Mexico

Site Status

Sint Antonius Ziekenhuis, locatie Nieuwegein

Nieuwegein, , Netherlands

Site Status

Erasmus Medisch Centrum

Rotterdam, , Netherlands

Site Status

Auckland City Hospital

Auckland, , New Zealand

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NZ Respiratory & Sleep Institute

Auckland, , New Zealand

Site Status

University of Otago, Christchurch

Christchurch, , New Zealand

Site Status

Waikato Hospital; Gastro Research

Hamilton, , New Zealand

Site Status

Tauranga Hospital

Tauranga, , New Zealand

Site Status

Helse Bergen HF Haukeland universitetssykehus; Hudavdelingen

Bergen, , Norway

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Akershus universitetssykehus

Lørenskog, , Norway

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Oslo University Hospital HF, Rikshospitalet

Oslo, , Norway

Site Status

Centrum Medycyny Oddechowej Mroz sp. j.

Bia?ystok, , Poland

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Nasz Lekarz Osrodek Badan Klinicznych

Bydgoszcz, , Poland

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SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, , Poland

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Hospital de Braga; Centro Clínico Académico (Piso 1, Ala E)

Braga, , Portugal

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Centro Hospitalar do Alto Ave; EPE

Guimarães, , Portugal

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Centro Hospitalar Universitario Lisboa Norte - Hospital Pulido Valente

Lisbon, , Portugal

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CHVNG/E_Unidade 1; Servico de Pneumologia

Vila Nova de Gaia, , Portugal

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National University Hospital

Singapore, , Singapore

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Singapore General Hospital

Singapore, , Singapore

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Tan Tock Seng Hospital; Oncology

Singapore, , Singapore

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University of Cape Town Lung Institute; Lung Clinical Research

Cape Town, , South Africa

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Vergelegen Medi-Clinic

Somerset West, , South Africa

Site Status

The Catholic University of Korea Bucheon St. Mary's Hospital

Gyeonggi-do, , South Korea

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Gacheon University Gil Medical Center

Namdong-gu, , South Korea

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Seoul National University Bundang Hospital

Seongnam-si, , South Korea

Site Status

The Catholic University of Korea Yeouido St. Mary's Hospital; Hematology-Oncology

Seoul, , South Korea

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Seoul National University Hospital (SNUH) - Medical Oncology Center

Seoul, , South Korea

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Soonchunhyang University Hospital

Seoul, , South Korea

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Asan Medical Center

Seoul, , South Korea

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Samsung Medical Center

Seoul, , South Korea

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Korea University Guro Hospital

Seoul, , South Korea

Site Status

HUA - Txagorritxu

Vitoria-Gasteiz, Alava, Spain

Site Status

Hospital Universitario de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Spain

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Corporació Sanitaria Parc Taulí; Servicio de Neurología

Sabadell, Barcelona, Spain

Site Status

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, Spain

Site Status

CHUS H Clinico U de Santiago

Santiago de Compostela, LA Coruña, Spain

Site Status

Hospital Universitario del Henares

Coslada, Madrid, Spain

Site Status

Hospital Univ. Central de Asturias

Oviedo, Principality of Asturias, Spain

Site Status

Hospital Galdakao-Usansolo

Galdakao, Vizcaya, Spain

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Hospital de la Santa Creu i Sant Pau; Servicio de Neumologia

Barcelona, , Spain

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Hospital Clinic I Provincial

Barcelona, , Spain

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Hospital Germans Trias i Pujol

Barcelona, , Spain

Site Status

Hospital Virgen de las Nieves; Servicio de Neumologia

Granada, , Spain

Site Status

Hospital Universitario de la Princesa; Servicio de Aparato Digestivo

Madrid, , Spain

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Clinica Universidad de Navarra ; Servicio de Farmacia

Madrid, , Spain

Site Status

Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz

Madrid, , Spain

Site Status

Hospital Ramón y Cajal;Servicio de Neumología

Madrid, , Spain

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Fundacion Jimenez Diaz-UTE

Madrid, , Spain

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Hosp. Clinico San Carlos

Madrid, , Spain

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Hospital Universitario 12 de Octubre

Madrid, , Spain

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Hospital Clinico Universitario Virgen de la Victoria

Málaga, , Spain

Site Status

Hospital Clinico Universitario de Salamanca

Salamanca, , Spain

Site Status

Hospital Clinico Universitario de Valencia

Valencia, , Spain

Site Status

Buddhist Tzu Chi Dalin General Hospital; Rheumatology

Chiayi City, , Taiwan

Site Status

Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital

Kaoshiung City, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

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National Cheng Kung University Hospital

Tainan City, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Far Eastern Memorial Hospital; Department of Clinical Pathology

Taipei, , Taiwan

Site Status

Veterans General Hospital - Taichung

Xitun Dist., , Taiwan

Site Status

Istanbul Universitesi Onkoloji Enstitüsü Hastanesi

?stanbul, , Turkey (Türkiye)

Site Status

Cukurova Universitesi Tip Fakultesi Balcali Hastanesi; Balcali

Adana, , Turkey (Türkiye)

Site Status

Ankara Universitesi Tip Fakultesi Hastaneleri - Cebeci Hastanesi

Ankara, , Turkey (Türkiye)

Site Status

Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi

Bursa, , Turkey (Türkiye)

Site Status

Gaziantep Universitesi Tip Fakultesi

Gaziantep, , Turkey (Türkiye)

Site Status

Yedikule Gogus Hastaliklari ve Gogus Cerrahisi Egitim ve Arastirma Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Ege Universitesi Tip Fakultesi Hastanesi

Izmir, , Turkey (Türkiye)

Site Status

Dokuz Eylul University Faculty of Medicine; Chest Diseases

Izmir, , Turkey (Türkiye)

Site Status

Kocaeli Universitesi Tip Fakultesi

Kocaeli, , Turkey (Türkiye)

Site Status

Marmara Universitesi Hastanesi Marmara University Hospital

Maltepe, , Turkey (Türkiye)

Site Status

Eriyes universitesi T?p Fakultesi Hastanesi

Melikgazi/Kayser, , Turkey (Türkiye)

Site Status

Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi

Mersin, , Turkey (Türkiye)

Site Status

Akdeniz University Faculty of Medicine Department of Pulmonology

Muratpasa/Antalya, , Turkey (Türkiye)

Site Status

Koc Universitesi (KU) Tip Fakultesi (Koc University School of Medicine)

Sarıyer, , Turkey (Türkiye)

Site Status

Countries

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United States Argentina Australia Belgium Canada China Czechia Denmark France Germany Greece Hong Kong Hungary Israel Italy Japan Mexico Netherlands New Zealand Norway Poland Portugal Singapore South Africa South Korea Spain Taiwan Turkey (Türkiye)

References

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Mantovani A, Garlanda C. Humoral Innate Immunity and Acute-Phase Proteins. N Engl J Med. 2023 Feb 2;388(5):439-452. doi: 10.1056/NEJMra2206346. No abstract available.

Reference Type DERIVED
PMID: 36724330 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2020-001429-30

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

WA42294

Identifier Type: -

Identifier Source: org_study_id

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