Determining the Age of First Acute Coronary Syndrome

NCT ID: NCT04578964

Last Updated: 2023-01-31

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-01-02
• Study Completion Date: 2024-06-01

Brief Summary

The study aimed to evaluate the association between the obesity grade and the age of the first acute coronary syndrome (ACS). The effect of cardiovascular (CV) risk factors and the age of first ACS in patients with severe obesity was also examined. Consecutive patients with diagnosis of first episode of ACS were prospectively enrolled in 2014 to 2024.Cardiovascular risks of patients will be determined according to clinical and laboratory evaluation and patients were categorized by their body mass indices (BMI). Independent variables that effected the age of first ACS were examined by linear regression analysis

Detailed Description

In the first stage, the first ACS diagnosis of the patients will be tried to be clarified. It will be tried to clarify whether the patients have had ACS before, according to their history, ecg echo and coronary angiography findings. Patients with previous ACS or uncertain ACS diagnosis will not be included in the study.

In the second stage, cardiovascular risk burdens of patients for whom the initial ACS diagnosis is clear will be revealed. Smoking, diabetes mellitus (DM), hypertension (HT), psychological stress, socio-economic status, migration history, cholesterol parameters will be determined. The duration and severity of these risk factors will be determined. In the final model, each risk factor will be examined in detail with its sub-tabs and the effect of each risk factor will be examined separately.

Eventually, a model will be developed that allows predicting the first ACS age. The shortcomings of this model and the narrow scope of the definition of the population will be determined and the direction will be determined for the studies that improve these points.

Conditions

Acute Coronary Syndrome; Age Problem; Risk Factor, Cardiovascular

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Adult patients with the diagnosis of the first acute coronary syndrome

Exclusion Criteria

• Previous cardiovascular disease
• Chronic renal disease,
• Chronic obstructive pulmonary disease,
• Malignancy,
• Regularly use of statins, antiplatelets or anticoagulants,
• Situations where oral communication cannot be established with the patient
• Situations when coronary angiography (CAG) could not be performed .
• Patients with findings that might be related to previous MI on electrocardiography (ECG) or echocardiography and total occlusion other than 'culprit' lesion and no critical stenosis on CAG

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Antalya Training and Research Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

Deniz Demirci

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Deniz Demirci

Antalya, , Turkey (Türkiye)

Site Status: RECRUITING

Countries

Turkey (Türkiye)

Central Contacts

Deniz Demirci, MD

Role: CONTACT

dddemirci@gmail.com

+905056847321

Facility Contacts

Deniz Demirci, MD

Role: primary

References

Demirci D, Demirci DE, Chi G. Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study. Int J Cardiol. 2022 Mar 15;351:93-99. doi: 10.1016/j.ijcard.2021.11.080. Epub 2021 Dec 2.

Reference Type: DERIVED

PMID: 34864079 (View on PubMed)

Other Identifiers

2014-097

Identifier Type: -

Identifier Source: org_study_id