The LADIES Acute Coronary Syndromes Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

675 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-04-30

Study Completion Date

2015-10-31

Brief Summary

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The Ladies ACS study will investigate the relation between age at menopause and severity of coronary artery disease in menopausal women with acute coronary syndromes and clinical indication to coronary angiography.

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Detailed Description

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Multicenter prospective study in consecutive patients hospitalized with a wide spectrum of ACS and clinical indication to coronary angiography.

Consecutive patients older than 55 years with an ACS undergoing coronary angiography are eligible for the study, irrespective of subsequent revascularization. Eligible are women and men with a 2:1 enrolment ratio.

Patients will be stratified according to gender and age, including four age categories: 55-64, 65-74, 75-85 and \>85 years. Each age category will include 200 patients, and enrolment in each category will be stopped once this number has been reached.

A specific electronic web-based CRF will collect clinical and procedural data. Clinical data input will take place at the participating Centers. Angiographic data input will be performed at rthe angiographic corelab, blinded of clinical data.

The e-CRF will collect data on

* the characteristics of the ACS
* the relevant risk factors for CAD and known prognostically relevant variables
* prior clinical history (prior MI, PCI, CABG, heart failure, stroke)
* in women fertility history will be captured by specific items, including age at first and last menstrual period, past use of oral contraceptives, ongoing and past hormone replacement therapy (HRT) and whether they had undergone a hysterectomy and/or oophorectomy, as well as information on the number of full-term pregnancies (the sum of live births and stillbirths). Age at menarche is defined as the age at the first menstrual period. Reproductive life span is automatically calculated calculated by subtracting the age at menarche from the age at menopause. The presence of hot flushes, their severity and duration in years will be also captured.

The extent of coronary artery disease will be evaluated at a central corelab using the Gensini score and the SYNTAX score

Conditions

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Acute Coronary Syndromes Menopause

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Stratification by gender and age, including 4 age categories

\>=55-64 years

No interventions assigned to this group

Age >=65 to 74

No interventions assigned to this group

Age >=75 to 84

No interventions assigned to this group

Age >=85

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Patients \>55 years of age with all of the following characteristics:

* symptoms suggestive of acute myocardial ischemia within the previous 48 hours.
* The diagnosis of an ACS must be confirmed by a typical rise and fall in serum troponin levels as defined by the Third Universal Definition of Myocardial Infarction.
* ECG signs of myocardial ischemia defined as either transient or persistent ST segment elevation or depression \>0.5 mm (but \>1 mm in the case of ST-segment elevation), or persistent and definite T-wave inversion \>1 mm, including the pseudonormalization of a previously negative T-wave, in ≥2 contiguous leads.