Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease
NCT ID: NCT00798122
Last Updated: 2025-07-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
50 participants
INTERVENTIONAL
2006-03-01
2027-07-01
Brief Summary
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It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again. Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way.
Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound (IVUS). IVUS involves creating pictures of the artery walls using ultrasound (sound waves) from within the artery itself. In some women without major heart artery blockage, heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS. This problem can be found using magnetic resonance imaging (MRI), which can show blood flow to the heart. MRI may also be used to show where the heart has been damaged. The pattern of damage could suggest that a heart attack in a woman, who has no badly blocked heart arteries, happened for one (or more) of these reasons or another reason.
The Study of Women with ACS and Non-obstructive CAD (SWAN) will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Women
IVUS and MRI performed in women with no obstructive CAD at angiography
Intravascular ultrasound
intravascular ultrasound
MRI
cardiac MRI
Interventions
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Intravascular ultrasound
intravascular ultrasound
MRI
cardiac MRI
Eligibility Criteria
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Inclusion Criteria
* positive cardiac markers and/or ST elevation
* scheduled for angiography
Exclusion Criteria
* contraindication to IVUS and/or MRI
* use of vasospastic agent
18 Years
FEMALE
No
Sponsors
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Doris Duke Charitable Foundation
OTHER
NYU Langone Health
OTHER
Responsible Party
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Principal Investigators
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Harmony Reynolds, M.D.
Role: PRINCIPAL_INVESTIGATOR
NYU Langone Health
Locations
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NYU Medical Center and Bellevue Hospital Center
New York, New York, United States
Countries
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References
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Reynolds HR, Srichai MB, Iqbal SN, Slater JN, Mancini GB, Feit F, Pena-Sing I, Axel L, Attubato MJ, Yatskar L, Kalhorn RT, Wood DA, Lobach IV, Hochman JS. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011 Sep 27;124(13):1414-25. doi: 10.1161/CIRCULATIONAHA.111.026542. Epub 2011 Sep 6.
Other Identifiers
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DD CSDA 2006066
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
07-050
Identifier Type: -
Identifier Source: org_study_id
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