Coronary Artery Plaque Burden in Stable Angina and Non-obstructive Coronary Artery Disease
NCT ID: NCT04009421
Last Updated: 2023-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
1400 participants
OBSERVATIONAL
2018-02-15
2028-12-31
Brief Summary
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The main objective of the project is to assess the association between coronary artery plaque features by coronary CT angiography and long term prognosis in a large unselected population undergoing CT coronary angiography due to stable angina and suspected myocardial ischemia from the Norwegian Registry for Invasive Cardiology (NORIC) diagnosed with non-obstructive CAD by coronary CT angiography.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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High and low coronary artery plaque burden
Patients with high plaque burden defined as plaque in \>=4 segments of the coronary tree and low plaque burden as plaque in \<4 segments of the coronary tree assessed by postprocessing of CT coronary angiography images and cardiovascular events and mortality.
Coronary artery plaque assessment by CT coronary angiography QAngio CT RE
Assessment of segmental plaque volume and composition
Interventions
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Coronary artery plaque assessment by CT coronary angiography QAngio CT RE
Assessment of segmental plaque volume and composition
Eligibility Criteria
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Inclusion Criteria
* Non-obstructive coronary artery disease by CT coronary angiography defined as \<50% stenosis (lumen diameter reduction)
Exclusion Criteria
* Unstable angina
* Previous myocardial infarction, heart surgery or percutaneous coronary interventions
18 Years
ALL
No
Sponsors
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Haukeland University Hospital
OTHER
University of Bergen
OTHER
Responsible Party
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Mai Tone Lønnebakken
Professor
Principal Investigators
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Mai Tone Lønnebakken, MD phd
Role: PRINCIPAL_INVESTIGATOR
University of Bergen
Locations
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Department of Clinical Science, University of Bergen
Bergen, , Norway
Countries
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References
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Hondros CAB, Hanseth S, Solvik M, Pedersen EKR, Khan I, Hovland S, Larsen TH, Lonnebakken MT. Age-stratified differences in coronary artery plaque phenotypes in women and men with non-obstructive coronary artery disease. Open Heart. 2025 Jul 11;12(2):e003371. doi: 10.1136/openhrt-2025-003371.
Khan I, Hondros CAB, Hanseth S, Pedersen ER, Hovland S, Larsen TH, Lonnebakken MT. Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease. Coron Artery Dis. 2025 Nov 1;36(7):580-586. doi: 10.1097/MCA.0000000000001539. Epub 2025 Jun 17.
Hondros CAB, Khan I, Solvik M, Hanseth S, Pedersen EKR, Hovland S, Larsen TH, Lonnebakken MT. Compositional plaque progression in women and men with non-obstructive coronary artery disease. Int J Cardiol Heart Vasc. 2024 Feb 7;51:101352. doi: 10.1016/j.ijcha.2024.101352. eCollection 2024 Apr.
Berge CA, Eskerud I, Almeland EB, Larsen TH, Pedersen ER, Rotevatn S, Lonnebakken MT. Relationship between hypertension and non-obstructive coronary artery disease in chronic coronary syndrome (the NORIC registry). PLoS One. 2022 Jan 21;17(1):e0262290. doi: 10.1371/journal.pone.0262290. eCollection 2022.
Other Identifiers
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1573
Identifier Type: -
Identifier Source: org_study_id